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SHBG

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Also known as: Testosterone-estrogen Binding Globulin; TeBG
Formal name: Sex Hormone Binding Globulin
Related tests: Testosterone, Free Testosterone, Bioavailable Testosterone, LH, Albumin, Estradiol, Prolactin

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NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used.

Sources Used for Current Review

Reviewer May 2015: Nicole V. Tolan, PhD, DABCC, Associate Director of Chemistry and POCT, BIDMC and Harvard Medical School.

Isbell TS, Jungheim E, Gronowski AM. Reproductive endocrinology and related disorders. In: Burtis CA, Ashwood ER, Burns DE, eds. Tietz textbook of clinical chemistry and molecular diagnostics, Vol. 5th ed: Elsevier, 2012.

Pugeat M, Crave JC, Tourniaire J, Forest MG. Clinical utility of sex hormone-binding globulin measurement. Horm Res 1996;45:148-55.

Wheeler MJ. The determination of bio-available testosterone. Ann Clin Biochem 1995;32:345-57.

Ly LP, Sartorius G, Hull L, Leung A, Swerdloff RS, Wang C, Handelsman DJ. Original article: Accuracy of calculated free testosterone formulae in men. Clinical Endocrinology 2010;73:382-

Sources Used for Previous Reviews

Thomas, Clayton L., Editor (1997). Taber's Cyclopedic Medical Dictionary. F.A. Davis Company, Philadelphia, PA [18th Edition].

Pagana, Kathleen D. & Pagana, Timothy J. (2001). Mosby's Diagnostic and Laboratory Test Reference 5th Edition: Mosby, Inc., Saint Louis, MO.

(© 2004). Sex Hormone Binding Globulin. ARUP's Guide to Clinical Laboratory Testing [On-line information]. Available online at http://www.arup-lab.com/guides/clt/tests/clt_193b.jsp#1147406 through http://www.arup-lab.com.

(© 2004). Testosterone, Bioavailable and Sex Hormone Binding Globulin. ARUP's Guide to Clinical Laboratory Testing [On-line information]. Available online at http://www.arup-lab.com/guides/clt/tests/clt_225b.jsp#1148913 through http://www.arup-lab.com.

Camillo, P. (2004 January 27). How Should I Handle Complaints of Decreased Libido in Female Patients? Medscape, Ask the Experts about Women's Health for Advanced Practice Nurses [On-line information]. Available online at http://www.medscape.com/viewarticle/466490?src=search through http://www.medscape.com.

Dennerstein, L. (2003 February 12). Depressed Libido in the Postmenopausal Woman. Medscape, Ask the Experts about Menopause [On-line information]. Available online at http://www.medscape.com/viewarticle/448554 through http://www.medscape.com.

Reuters Health (2004 February 4). Postmenopausal Endogenous Hormones Influence Endometrial Cancer Risk. National Cancer Institute [On-line News]. Available online at http://ctep.info.nih.gov/resources/gcig/news020404.html through http://ctep.info.nih.gov.

Tenover, J. (2001). Male Hormone Replacement Therapy Including "Andropause."  WellMax.org [On-line News, Essays & Articles]. Available online at http://www.wellmax.org/NewsPub/Stories/2001/05/07/9892607709.html through http://www.wellmax.org.

Patient's Guide to Low Testosterone, 2003 Edition. Medem Medical Library [On-line information by The Hormone Foundation and Endocrine Society]. Available online at http://www.medem.com/medlb/article_detaillb.cfm?article_ID=ZZZO7PDVDLC&sub_cat=57 through http://www.medem.com.

Snyder, P. (2003 September 9). Testes and Testicular Disorders. Medscape, from WebMD Scientific American® Medicine 2003, What's New in Medicine [On-line information]. Available online at http://www.medscape.com/viewarticle/461007 through http://www.medscape.com.

Allan, C. and McLachlan, R. (2004 June 3). Age-Related Changes in Testosterone and the Role of Replacement Therapy in Older Men. Medscape, from Clin Endocrinol 60(6): 653-670, 2004 [On-line journal article]. Available online at http://www.medscape.com/viewarticle/479523?src=search through http://www.medscape.com.

Matsumoto, A. (2008 June 27). Diagnosis and Evaluation of Male Hypogonadism CME. Medscape Today, Selection from: Men's Sexual Health Consult Collection: Testosterone Replacement Therapy in the VA Setting [On-line information]. Available online at http://www.medscape.com/viewarticle/575491 through http://www.medscape.com. Accessed on 7-30-08.

Chang, R. (2007 September 14). The Reproductive Phenotype in Polycystic Ovary Syndrome CME. Medscape From Nature Clinical Practice Endocrinology & Metabolism [On-line information]. Available online at http://www.medscape.com/viewarticle/562712 through http://www.medscape.com. Accessed on 7-30-08.

Sabatini, L. (2007 May 29, Updated). Androgen Excess. emedicine [On-line information]. Available online at http://www.emedicine.com/med/TOPIC3489.HTM through http://www.emedicine.com. Accessed on 7-30-08.

Anawalt, B. (2007 June Reviewed). Male Reproductive Endocrinology, Introduction. Merck Manual for Healthcare Professionals [On-line information]. Available online at http://www.merck.com/mmpe/sec17/ch227/ch227a.html?qt=SHBG&alt=sh through http://www.merck.com. Accessed on 7-30-08.

Anawalt, B. (Revised 2010 January). Male Reproductive Endocrinology. The Merck Manual for Healthcare Professionals [On-line information]. Available online through http://www.merckmanuals.com. Accessed January 2012.

Dandona, P and Rosenberg, M. (2010 May 10). A Practical Guide to Male Hypogonadism in The Primary Care Setting: Clinical Presentation and Diagnosis. Medscape Today News from Int J Clin Pract. 2010;64(6):682-696 [On-line information]. Available online at http://www.medscape.com/viewarticle/721069_4 through http://www.medscape.com. Accessed January 2012.

Peter, A. et. al. (2010 December 16). Relationships of Circulating Sex Hormone–Binding Globulin with Metabolic Traits in Humans. Medscape Today News from Diabetes. 2010;59 (12) [On-line information]. Available online at http://www.medscape.com/viewarticle/733605 through http://www.medscape.com. Accessed January 2012.

(Updated © 1995-2012). Test ID: SHBG9285 Sex Hormone-Binding Globulin (SHBG), Serum Mayo Clinic Mayo Medical Laboratories [On-line information]. Available online at http://www.mayomedicallaboratories.com/test-catalog/Overview/9285 through http://www.mayomedicallaboratories.com. Accessed January 2012.

(Updated 2011 July). Hypogonadism, Male. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/HypogonadismMale.html?client_ID=LTD#tabs=0 through http://www.arupconsult.com. Accessed January 2012.

Lucidi, R. et. al. (Updated 2011 October 25). Polycystic Ovarian Syndrome. Medscape Reference [On-line information]. Available online at http://emedicine.medscape.com/article/256806-overview through http://emedicine.medscape.com. Accessed January 2012.

Pagana, K. D. & Pagana, T. J. (© 2011). Mosby’s Diagnostic and Laboratory Test Reference 10th Edition: Mosby, Inc., Saint Louis, MO. Pp 928-930.

Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. Burtis CA, Ashwood ER, Bruns DE, eds. St. Louis: Elsevier Saunders; 2006, 2011-2012.

Maggio M, et al. Sex hormone binding globulin levels across the adult lifespan in women - The role of body mass index and fasting insulin. J Endocrinol Invest. 2008 July; 31(7): 597–601. Available online at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648802/ through http://www.ncbi.nlm.nih.gov. Accessed February 2012.

Kelly JA, Vankrieeken L. Sex hormone binding globulin and the assessment of androgen status. Available online through http://www.medical.siemens.com. Accessed February 2012.