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Sickle Cell Tests

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Also known as: Hemoglobin S; Hb S; Hgb S
Formal name: Hemoglobin S Evaluation
Related tests: Hemoglobin Electrophoresis; Hemoglobin Isoelectric Focusing; Hemoglobin S Solubility; Hemoglobin Fractionation by HPLC; Hemoglobinopathy Evaluation; Complete Blood Count; Blood Smear; Iron Tests

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NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used.

Sources Used in Current Review

Sickle Cell Anemia. (Updated Feb. 7, 2012). MedlinePlus Medical Encyclopedia. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/000527.htm. Accessed August 2013.

Sickle Cell Disease. (Updated Sept. 15, 2011). Centers for Disease Control and Prevention. Available online at http://www.cdc.gov/ncbddd/sicklecell/treatments.html through http://www.cdc.gov/ncbddd. Accessed August 2013.

Sickle Cell Test. (Updated Feb. 28, 2011). MedlinePlus Medical Encyclopedia. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003666.htm. Accessed August 2013.

Sickle cell anemia on rise in newborns worldwide. (Published July 16, 2013). U.S. News and World Report Online. Available at http://health.usnews.com/health-news/news/articles/2013/07/16/sickle-cell-anemia-on-rise-in-newborns-worldwide through http://health.usnews.com. Accessed August 2013.

Sources Used in Previous Reviews

(2006 May). What is Sickle Cell Anemia. National Heart, Lung and Blood Institute Information Center [On-line information]. Available online at http://www.nhlbi.nih.gov/health/dci/Diseases/Sca/SCA_WhatIs.html through http://www.nhlbi.nih.gov.

Bender, M.A. (2006 March 7, Updated). Sickle Cell Disease. GeneReviews [On-line information]. Available online through http://www.genetests.org.

(© 2006). Hemoglobin Evaluation. ARUP’s Guide to Clinical Laboratory Testing [On-line information]. Available online at http://www.aruplab.com/guides/clt/tests/clt_a307.jsp#1150784 through http://www.aruplab.com.

(2004). Interpretation of Newborn Hemoglobin Screening Results. Michigan Department of Community Health [On-line information]. Available online through http://www.michigan.gov.

(2004 August). Sickle Cell Disease. March of Dimes, Quick Reference Fact Sheets [On-line information]. Available online at http://www.marchofdimes.com/professionals/681_1221.asp through http://www.marchofdimes.com.

Raj, A. and Bertolone, S. (Updated 2009 July 9). Sickle Cell Anemia. eMedicine [On-line information]. Available online at http://emedicine.medscape.com/article/958614-overview through http://emedicine.medscape.com. Accessed September 2009.

Bender, M. A. and Hobbs, W. (Updated 2009 August 6). Sickle Cell Disease GeneReviews [On-line information]. Available online at http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene∂=sickle through http://www.ncbi.nlm.nih.gov. Accessed September 2009.

Hildreth, C. et. al. (2008 December 10). Sickle Cell Vasculopathy. JAMA. 2008;300(22):2690 [On-line information]. PDF available for download at http://jama.ama-assn.org/cgi/reprint/300/22/2690.pdf through http://jama.ama-assn.org. Accessed September 2009.

Mayo Clinic Staff (2009 April 1). Sickle cell anemia. MayoClinic.com [On-line information]. Available online at http://www.mayoclinic.com/health/sickle-cell-anemia/DS00324/METHOD=print through http://www.mayoclinic.com. Accessed September 2009.

(2008 February). Sickle Cell Disease. March of Dimes Fact Sheets [On-line information]. Available online at http://www.marchofdimes.com/professionals/14332_1221.asp through http://www.marchofdimes.com. Accessed September 2009.

(Reviewed 2009 June 9). Sickle Cell Disease: 10 Things You Need to Know. CDC [On-line information]. Available online at http://www.cdc.gov/Features/Sicklecell/ through http://www.cdc.gov. Accessed September 2009.

(2008 August). Sickle Cell Anemia. National Heart, Lung, and Blood Institute [On-line information]. Available online at http://www.nhlbi.nih.gov/health/dci/Diseases/Sca/SCA_WhatIs.html through http://www.nhlbi.nih.gov. Accessed September 2009.

Pagana, K. D. & Pagana, T. J. (© 2007). Mosby's Diagnostic and Laboratory Test Reference 8th Edition: Mosby, Inc., Saint Louis, MO. Pp 523-525.

Clarke, W. and Dufour, D. R., Editors (© 2006). Contemporary Practice in Clinical Chemistry: AACC Press, Washington, DC. Pp 219-223.

Wu, A. (© 2006). Tietz Clinical Guide to Laboratory Tests, 4th Edition: Saunders Elsevier, St. Louis, MO. Pp 518-521.

(October 5, 2009) National Guideline Clearinghouse. Screening for sickle cell disease in newborns: U.S. Preventive Services Task Force recommendation statement. Available online at http://www.guideline.gov/summary/summary.aspx?doc_id=11371&nbr=005908&string=sickle+AND+cell+AND+anemia through http://www.guideline.gov. Accessed October 2009.