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Sirolimus

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Also known as: Rapamycin; [Often referred to by brand name (see MedlinePlus Drug Information)]
Formal name: Sirolimus

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NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used.

Sources Used in Current Review

Sirolimus. MedlinePlus. Available online at http://www.nlm.nih.gov/medlineplus/druginfo/meds/a602026.html through http://www.nlm.nih.gov. Last reviewed February 11, 2012. Accessed December 10, 2014.

Rapamune. Rx List. Available online at http://www.rxlist.com/rapamune-drug.htm through http://www.rxlist.com. Last reviewed January 14, 2013. Accessed December 10, 2014.

Sirolimus (Oral Route). Mayo Clinic. Available online at http://www.mayoclinic.org/drugs-supplements/sirolimus-oral-route/description/drg-20068199 through http://www.mayoclinic.org. Last updated September 1, 2014. Accessed December 10, 2014.

Henry's Clinical Diagnosis and Management by Laboratory Methods. 22nd ed. McPherson R, Pincus M, eds. Philadelphia, PA: Saunders Elsevier: 2011, Pp 354-355.

Sources Used in Previous Reviews

Clarke, W. and Dufour, D. R., Editors (2006). Contemporary Practice in Clinical Chemistry, AACC Press, Washington, DC. Pg 462.

Wu, A. (2006). Tietz Clinical Guide to Laboratory Tests, Fourth Edition. Saunders Elsevier, St. Louis, Missouri. Pp 1482-1485.

Buck, M. (2006 March 13). Immunosuppression with Sirolimus after Solid Organ Transplantation in Children [24 paragraphs]. Medscape from Pediatr Pharm 2006;12(2) [On-line information]. Available online at http://www.medscape.com/viewarticle/524753_1 through http://www.medscape.com. Accessed 11/2/07.

Aradhye, S et. al. (2006 December, Revised). Medicines for Keeping Your New Kidney Healthy. American Society of Transplantation [On-line information]. PDF available for download through http://www.a-s-t.org. Accessed 11/4/07.

American Society of Health-System Pharmacists, Inc. (2004 January, Revised). Sirolimus. AHFS [On-line information]. Available online at http://www.ashp.org/mngrphs/ahfs/a300009.htm through http://www.ashp.org. Accessed 11/2/07.

(2003 January 01, Revised). Sirolimus. MedlinePlus Drug Information [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a602026.html. Accessed 11/1/07.

(2007 September 13). Drug-Coated Stents Go Head to Head. MedlinePlus Health Day [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/news/fullstory_54789.html through http://www.nlm.nih.gov. Accessed 11/1/07.

(2007 March). Pancreatic Islet Transplantation. National Diabetes Information Clearinghouse [On-line information]. Available online at http://diabetes.niddk.nih.gov/dm/pubs/pancreaticislet/ through http://diabetes.niddk.nih.gov. Accessed 11/1/07.

Lexi-Comp (2007 June, Revised). Sirolimus. Merck Manual Professional [On-line information]. Available online at http://www.merck.com/mmpe/lexicomp/sirolimus.html through http://www.merck.com. Accessed 11/2/07.

(© 2007). Sirolimus. ARUP's Laboratory Test Directory [On-line information].  Available online at http://www.aruplab.com/guides/ug/tests/0098467.jsp through http://www.aruplab.com. Accessed 11/1/07.

(© 2007). Sirolimus (Rapamune ®), Blood. Labcorp Test Directory [On-line information]. Available online at http://www.labcorp.com/datasets/labcorp/html/chapter/ through http://www.labcorp.com. Accessed 11/1/07.

(© 2007). Sirolimus (Rapamycin). Quest Diagnostics Test Menu [On-line information]. Available online through http://cas2.questdiagnostics.com. Accessed 11/2/07.

(© 2007). Sirolimus MonitR. Specialty Laboratories Test Menu [On-line information]. Available online at http://www.specialtylabs.com/tests/details.asp?id=4940 through http://www.specialtylabs.com. Accessed 11/2/07.

(October 10, 2003) Transplant Living: Sirolimus. Available online through http://www.transplantliving.org. Accessed July 2011.

(July 14, 2009) U.S. Food and Drug Administration. Information for Healthcare Professionals: Immunosuppressant Drugs: Required Labeling Changes. Available online through http://www.fda.gov/. Accessed July 2011.

Food and Drug Administration. Prescribing Information (Approval 1999). PDF available for download at http://www.accessdata.fda.gov/drugsatfda_docs/label/2008/021083s033,021110s043lbl.pdf through http://www.accessdata.fda.gov. Accessed July 2011.

(©2011) Cleveland Clinic. Transplant programs: Sirolimus. Available online at http://my.clevelandclinic.org/transplant/services/kidney/sirolimus.aspx through http://my.clevelandclinic.org. Accessed July 2011.

(©2011) eMedicine Health. Drugs and Medications, Rapamune. Available online at http://www.emedicinehealth.com/drug-sirolimus/article_em.htm through http://www.emedicinehealth.com. Accessed July 2011.

Clarke, W. and Dufour, D. R., Editors (2006). Contemporary Practice in Clinical Chemistry, AACC Press, Washington, DC. Pg 462.

Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. 4th ed., Burtis CA and Ashwood ER, eds. Philadelphia: W. B. Saunders Company; 2005. Pp 1278-1280.

(2010 February 10, Revised). MedlinePlus Drug InformationSirolimus [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a602026.html. Accessed July 2011.

(2007 March) National Diabetes Information Clearinghouse. Pancreatic Islet Transplantation [On-line information]. Available online at http://diabetes.niddk.nih.gov/dm/pubs/pancreaticislet/ through http://diabetes.niddk.nih.gov. Accessed July 2011.

Van de Beek, D et al. No Major Neurologic Complications With Sirolimus Use in Heart Transplant Recipients. Mayo Clinic Proceedings April 2009 vol. 84 no. 4 330-332. Available online at http://www.mayoclinicproceedings.com/content/84/4/330.full through http://www.mayoclinicproceedings.com. Accessed July 2011.