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Sweat Chloride Test

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Also known as: Sweat Electrolytes; Iontophoretic Sweat Test
Formal name: Sweat Chloride

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NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used. To access online sources, copy and paste the URL into your browser.

Sources Used in Current Review

Sharma, G. (2016 June 08 Updated). Cystic Fibrosis. Medscape Drugs and Diseases. Available online at http://emedicine.medscape.com/article/1001602-overview. Accessed on 9/05/16.

Kaneshiro, N. (2015 April 21 Update). Sweat electrolytes test. MedlinePlus Medical Encyclopedia. Available online at https://medlineplus.gov/ency/article/003630.htm. Accessed on 9/05/16.

(2016 August Updated). Cystic Fibrosis - CF. ARUP Consult. Available online at https://arupconsult.com/content/cystic-fibrosis/?tab=tab_item-0. Accessed on 9/05/16.

Gupta, R. (2015 August Reviewed). Cystic Fibrosis (CF) Chloride Sweat Test. KidsHealth from Nemours. Available online at http://kidshealth.org/en/parents/sweat-test.html. Accessed on 9/05/16.

Sweat Test. Cystic Fibrosis Foundation. Available online at https://www.cff.org/What-is-CF/Testing/Sweat-Test/. Accessed on 9/05/16.

(2013 December 26). Cystic Fibrosis. National Heart Lung and Blood Institute. Available online at http://www.nhlbi.nih.gov/health/health-topics/topics/cf. Accessed on 9/05/16.

Guidelines for Diagnosis of Cystic Fibrosis in Newborns through Older Adults: Cystic Fibrosis Foundation Consensus Report. August 2008, Volume 153, Issue 2, Pages S4–S14. Available online at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810958/. Accessed November 2016.

Oct. 13, 2016. Mayo Clinic. Cystic Fibrosis. Available online at http://www.mayoclinic.org/diseases-conditions/cystic-fibrosis/diagnosis-treatment/diagnosis/dxc-20211900. Accessed November 2016.

©Johns Hopkins Cystic Fibrosis Center. Diagnosis: Testing: Sweat Test. Available online at http://www.hopkinscf.org/what-is-cf/diagnosis/testing/sweat-test/. Accessed November 2016.

Sources Used in Previous Reviews

Thomas, Clayton L., Editor (1997). Taber's Cyclopedic Medical Dictionary. F.A. Davis Company, Philadelphia, PA [18th Edition].

Pagana, Kathleen D. & Pagana, Timothy J. (2001). Mosby's Diagnostic and Laboratory Test Reference 5th Edition: Mosby, Inc., Saint Louis, MO.

NIDDK (July 1997). Cystic Fibrosis Research Directions. The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) [NIH Publication No. 97-4200]. Available online at http://www.niddk.nih.gov/health/endo/pubs/cystic/cystic.htm.

CFF. Sweat Testing Procedure and Commonly Asked Questions. Cystic Fibrosis Foundation [On-line information]. Available online at http://www.cff.org/publications01.htm.

Tait, J., et. al. (26 March 2001). Cystic Fibrosis. GENEReviews [On-line information]. Available online at http://www.genetests.org/.

Mayo Clinic (2001, February 09). What is Cystic Fibrosis? Mayo Clinic [On-line information]. Available online at http://www.mayoclinic.com/invoke.cfm?objectid=2CEBF76F-D36A-4D15-B937BFF91AB51438.

NIH (2002, January 2, Updated). Cystic Fibrosis. MedlinePlus Health Information [On-line Information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/000107.htm.

NIH (2002, January 2, Updated). Sweat Electrolytes. MedlinePlus Health Information [On-line Information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003630.htm.

NIH (2002, January 2, Updated). Trypsin and chymotrypsin in stool. MedlinePlus Health Information [On-line Information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003594.htm.

Mountain States Genetics (1999, September, Revised). Cystic Fibrosis (CF). Newborn Screening Practitioner’s Manual [On-line information]. Available online at http://www.mostgene.org/pract/prac26.htm.

National Institutes of Health (1995, November). Facts About Cystic Fibrosis. National Heart, Lung, and Blood Institute NIH Publication No. 95-3650 [On-line information]. Available online at http://www.nhlbi.nih.gov/health/public/lung/other/cf.htm.

Quest Diagnostics NEWS (2002, Winter). What is the Best Test to Screen for Cystic Fibrosis? [On-line serial]. PDF available for download at http://www.questdiagnostics.com/hcp/files/02winter_newsletter.pdf.

NIH (2002, January 2, Updated). Neonatal cystic fibrosis screening. MedlinePlus Health Information [On-line Information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003409.htm.

Drkoop (2001). Cystic fibrosis. Medical Encyclopedia [On-line information]. Available online at http://www.drkoop.com/conditions/ency/article/000107.htm.

NIH (2002, January 2, Updated). Trypsinogen. MedlinePlus Health Information [On-line Information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003560.htm.

Biomedical Hypertext (1999 May 20, last update). Exocrine Secretions of the Pancreas. Colorado State University [On-line information]. Available online at http://arbl.cvmbs.colostate.edu/hbooks/pathphys/digestion/pancreas/exocrine.html.

UPCMD (1998 – 2002). Cystic Fibrosis. University Pathology Consortium, LLC [On-line information]. Available online at http://www.upcmd.com/dot/examples/00218/description.html.

Sainato, D., (2002, March). Genetic Testing for CF Going Mainstream? Clinical Laboratory News, Volume 28.

Peter Jacky, PhD, FACMG. Director of Cytogenetics and Molecular Genetics, Airport Way Regional Laboratory, Portland, OR.

(June 2008) American Lung Association. Cystic Fibrosis Factsheet. Available online at http://www.lungusa.org/site/apps/nlnet/content3.aspx?c=dvLUK9O0E&b=2058829&content_id={2C5B0EF6-D044-4306-AF93-416DE1C89DE8}&notoc=1. Accessed January 2009.

Cystic Fibrosis Foundation. Testing for Cystic Fibrosis, The Sweat Test. Available online at http://www.cff.org/AboutCF/Testing/SweatTest/. Accessed January 2009.

(June 2006) Coffin, C. Nemours Foundation. Sweat Test. Available online at http://kidshealth.org/parent/general/sick/sweat_test.html. Accessed January 2009.

Pagana K, Pagana T. Mosby's Manual of Diagnostic and Laboratory Tests. 3rd Edition, St. Louis: Mosby Elsevier; 2006. Pp 707-709.

Cleveland Clinic. Cystic Fibrosis. Available online at http://my.clevelandclinic.org/disorders/cystic_fibrosis/hic_cystic_fibrosis.aspx#. Accessed January 2009.

Denise I. Quigley, PhD, FACMG. Co-Director Cytogenetics/Molecular Genetics, Airport Way Regional Laboratory, Portland, OR.

Peter Jacky, PhD, FACMG. Director of Cytogenetics and Molecular Genetics, Airport Way Regional Laboratory, Portland, OR.

Hadjiliadis, D. (Updated 2011 May 1). Sweat electrolytes test. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003630.htm. Accessed August 2012.

Sharma, G. (2012 May 15). Cystic Fibrosis. Medscape Reference [On-line information]. Available online at http://emedicine.medscape.com/article/1001602-overview. Accessed August 2012.

Cotton, S. et. al. (2012 February 26). Multiple Positive Sweat Chloride Tests in an Infant Asymptomatic for Cystic Fibrosis. Medscape Today News from Lab Med v43 (2):1-5. [On-line information]. Available online at http://www.medscape.com/viewarticle/758468. Accessed September 2012.

Ooi, C. et. al. (2012 July 27). Comparing the American and European Diagnostic Guidelines for Cystic Fibrosis Same Disease, Different Language? Medscape Today News from Thorax. v67 (7):618-624. [On-line information]. Available online at http://www.medscape.com/viewarticle/766511. Accessed September 2012.

Boas, S. et. al. (2012 April 27). Results of a Quality Improvement Program for Sweat Testing to Diagnose Cystic Fibrosis. Medscape Today News from Lab Med v43 (4):12-14 [On-line information]. Available online at http://www.medscape.com/viewarticle/762278. Accessed September 2012.

Bender, L. et. al. (2011 September 29). Kids in America Newborn Screening for Cystic Fibrosis. Medscape Today News from Lab Med v42 (10):595-601 [On-line information]. Available online at http://www.medscape.com/viewarticle/750133. Accessed September 2012.

Pagana, K. D. & Pagana, T. J. (© 2011). Mosby's Diagnostic and Laboratory Test Reference 10th Edition: Mosby, Inc., Saint Louis, MO. Pp 924-925

Timothy S. Uphoff, Ph.D., D(ABMG), MLS(ASCP)CM. Section Head Molecular Pathology Laboratory, Marshfield Labs, Marshfield Clinic, Marshfield WI.