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T-Cell Receptor Gene Rearrangement

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Also known as: T-cell Gene Clonality; TCGR; TCR Gene Rearrangement
Formal name: T-Cell Receptor Gene Rearrangement

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NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used. To access online sources, copy and paste the URL into your browser.

Sources Used in Current Review

(2017 March 24 Revised). Types of Non-Hodgkin Lymphoma. American Cancer Society. Available online at https://www.cancer.org/cancer/non-hodgkin-lymphoma/about/types-of-non-hodgkin-lymphoma.html. Accessed on 05/01/17.

(© 1995–2017). T-Cell Receptor Gene Rearrangement, PCR, Blood. Mayo Clinic Mayo Medical Laboratories. Available online at http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/83122. Accessed on 05/01/17.

Chitgopeken, P. and Sahni, D. (2014 April). T-Cell Receptor Gene Rearrangement Detection in Suspected Cases of Cutaneous T-Cell Lymphoma. Journal of Investigative Dermatology (2014), Volume 134. Available online at http://www.jidonline.org/article/S0022-202X(15)36699-9/fulltext?cc=y=. Accessed on 05/01/17.

Yu, Y. et. al. (2015 October 7). LymAnalyzer: a tool for comprehensive analysis of next generation sequencing data of T cell receptors and immunoglobulins. Nucleic Acids Res. 2016 Feb 29; 44(4): e31. Available online at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770197/. Accessed on 05/01/17.

Pinter-Brown, L. and Schwartz, R. (2016 January 15 Updated). Cutaneous T-Cell Lymphoma. Medscape Drugs & Diseases. Available online at http://emedicine.medscape.com/article/2139720-overview. Accessed on 05/01/17.

Kelley, T. et. al. (2017 April, Updated). Lymphomas, T-Cell/NK-Cell - T-Cell/NK-Cell Lymphomas. ARUP Consult. Available online at https://arupconsult.com/content/lymphomas-t-cellnk-cell/?tab=tab_item-0. Accessed on 05/01/17.

Issuree, P. et. al. (2017 March 22). Heritable Gene Regulation in the CD4:CD8 T Cell Lineage Choice. Front Immunol. 2017; 8: 291. Available online at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360760/. Accessed on 05/01/17.

Sources Used in Previous Reviews

Leonard, D. G. B., Editor (© 2009). Molecular Pathology in Clinical Practice: Oncology. Springer Science + Business Media, LLC., New York, NY. Pp 195-201.

(© 1995-2012). Test ID: TCGR83122 T-Cell Receptor Gene Rearrangement, PCR, Blood. Mayo Clinic Mayo Medical Laboratories [On-line information]. Available online at http://www.mayomedicallaboratories.com/test-catalog/print/83122. Accessed July 2012.

Bahler, D. et. al. (Updated 2012 May). Lymphomas, T/NK-Cell - T/NK-Cell Lymphomas. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/LymphomasTCell.html#tabs=0. Accessed June 2012.

Pinter-Brown. L. (Updated 2011 May 17). Cutaneous T-Cell Lymphoma Overview of CTCL. Medscape Reference [On-line information]. Available online at http://emedicine.medscape.com/article/209091-overview. Accessed June 2012.

Weissmann, D. (Revised 2006 May 18). Hematopathology, T-Cell Lymphomas. University of Medicine and Dentistry of New Jersey [On-line information]. Available online at http://pleiad.umdnj.edu/~dweiss/T-cell/T-cell.html. Accessed July 2012.

Hodges, E. et. al. (2003) Diagnostic role of tests for T cell receptor (TCR) genes. Clin Pathol v 56:1-11 doi:10.1136/jcp.56.1.1 [On-line information]. Available online at http://jcp.bmjjournals.com/content/56/1/1.full. Accessed July 2012.

Zhu, D. et. al. (2001). Detection of Clonal T-Cell Receptor-gamma Gene Rearrangement by PCR/Temporal Temperature Gradient Gel Electrophoresis. Am J Clin Pathol 2001;116:527-534 [On-line information]. PDF available for download at http://ajcp.ascpjournals.org/content/116/4/527.full.pdf. Accessed July 2012.

(Revised 2012 January 26). Non-Hodgkin Lymphoma American Cancer Society [On-line information]. Available online at http://www.cancer.org/Cancer/Non-HodgkinLymphoma/DetailedGuide/non-hodgkin-lymphoma-types-of-non-hodgkin-lymphoma. Accessed July 2012.

Kim, Y. (Revised 2011 October). Cutaneous T-Cell Lymphoma Facts. Leukemia and Lymphoma Society [On-line information]. PDF available for download at http://www.lls.org/content/nationalcontent/resourcecenter/freeeducationmaterials/lymphoma/pdf/cutaneoustcelllymphoma.pdf. Accessed July 2012.

(Updated 2012 February 16). Leukemia - T-Cell. American Society of Clinical Oncology [On-line information]. Available online at http://www.cancer.net/patient/Cancer+Types/Leukemia+-+T-Cell. Accessed July 2012.

(2011 December). T-Cell Receptor (TCR) Gene Rearrangement. Quest Diagnostics [On-line information]. Available online at http://www.questdiagnostics.com/testcenter/testguide.action?fn=Leuk_Lymph/TH_T-Cell.htm&redirectFrom=search. Accessed June 2012.

Delves, P. (Revised 2008 September). Components of the Immune System. Merck Manual for Healthcare Professionals [On-line information]. Available online through http://www.merckmanuals.com. Accessed June 2012.