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Thiopurine methyltransferase (TPMT)

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Also known as: TPMT RBC; TPMT Genotype; TPMT Phenotype
Formal name: Thiopurine S-methyltransferase Phenotype; Thiopurine S-methyltransferase Genotype

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NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used. To access online sources, copy and paste the URL into your browser.

Sources Used in Current Review

Johnson-Davis, K. (2017 February Updated). Thiopurine Methyltransferase Testing – TPMT. ARUP Consult. Available online at https://arupconsult.com/content/thiopurine-methyltransferase-testing. Accessed on 3/19/17.

Torkamani, A. (2015 October 21 Updated). Azathioprine Metabolism and TPMT. Medscape Drugs and Diseases. Available online at http://emedicine.medscape.com/article/1829596-overview. Accessed on 3/19/17.

(2015 April Reviewed). thiopurine S-methyltransferase deficiency. Genetics Home Reference. Available online at https://ghr.nlm.nih.gov/condition/thiopurine-s-methyltransferase-deficiency. Accessed on 3/19/17.

Zur, R. et. al. (2016 August). Thiopurine S-methyltransferase testing for averting drug toxicity: a meta-analysis of diagnostic test accuracy. Pharmacogenomics J. 2016 Aug;16(4):305-11. Available online at https://www.ncbi.nlm.nih.gov/pubmed/27217052. Accessed on 3/19/17.

(© 1995–2017). Thiopurine Methyltransferase (TPMT) Genotyping, Blood. Mayo Clinic Mayo Medical Laboratories. Available online at http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/62753. Accessed on 3/19/17.

Rowe, W. and Lichtenstein, G. (2016 June 17 Updated).Inflammatory Bowel Disease. Medscape Drugs and Diseases. Available online at http://emedicine.medscape.com/article/179037-overview. Accessed on 3/19/17.

(© 1995–2017). Thiopurine Methyltransferase (TPMT) Activity Profile, Erythrocytes. Mayo Clinic Mayo Medical Laboratories. Available online at http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/65188. Accessed on 3/19/17.

Sources Used in Previous Reviews

Dr. Jonathon Berg. City Hospital, Birmingham, England.

Clarke, W. and Dufour, D. R., Editors (2006). Contemporary Practice in Clinical Chemistry, AACC Press, Washington, DC. Pp. 479.

Wu, A. (2006). Tietz Clinical Guide to Laboratory Tests, Fourth Edition. Saunders Elsevier, St. Louis, Missouri. Pp. 1420.

(2008 July). Thiopurine Methyltransferase, Red Blood Cell. ARUP Laboratories Technical Bulletin [On-line information]. PDF available for download at http://www.aruplab.com/Testing-Information/resources/TechnicalBulletins/Thiopurine%20Methyltransferase,%20Red%20Blood%20Cell.pdf. Accessed on 1/4/09.

Ansari, A.et. al (2008 December 17). Prospective Evaluation of the Pharmacogenetics of Azathioprine in the Treatment of Inflammatory Bowel Disease [On-line information]. Available online at http://www.medscape.com/viewarticle/584257. Accessed on 1/4/09.

Aberra, F. and Lichtenstein, G. (Review Article: Monitoring of Immunomodulators in Inflammatory Bowel Disease. Medscape from Aliment Pharmacol Ther. 2005; 21 (4): 307-319. [On-line information]. Available online at http://www.medscape.com/viewarticle/499922_1. Accessed on 1/4/09.

Derijks, L. et. al. (2006 September 26). Thiopurines in Inflammatory Bowel Disease. [On-line information]. Available online at http://www.medscape.com/viewarticle/543562. Accessed on 1/4/09.

Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. Burtis CA, Ashwood ER and Bruns DE, eds. 4th ed. St. Louis, Missouri: Elsevier Saunders; 2006, Pg 1273.

Linnea Baudhuin, Phd, DABMG. Assistant Professor of Laboratory Medicine. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.

Nguyen et al. (May 15, 2011). Thiopurine methyltransferase (TPMT) genotyping to predict myelosuppression risk. PLoS Currents. Evidence on Genomic Tests. Available online at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094768/. Accessed March 2013.

(2013). Thiopurine Methyltransferase, Red Blood Cell. ARUP Laboratories. Available online at http://www.aruplab.com/guides/ug/tests/0092066.jsp. Accessed March 2013.

(Updated Oct. 2011). TPMT Genotype. Quest Diagnostics.Available online at http://www.questdiagnostics.com/testcenter/testguide.action?dc=TS_TPMT_Genotype. Accessed March 2013.

Azathioprine Metabolism and TPMT. Medscape. Available online at http://emedicine.medscape.com/article/1829596-overview. Accessed March 2013.

(2003) Relling, M. Genetics and Anti-Leukemia Therapy: The TPMT Story. American Childhood Cancer Organization. Available online at http://www.acco.org/Information/tpmt.aspx. Accessed April 2013.

Bruns D, Ashwood E, Burtis C, eds (2007). Fundamentals of Molecular Diagnostics, Saunders Elsevier, St. Lous, Missouri, Pp 200-203.