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TPMT

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Also known as: Thiopurine methyltransferase; TPMT RBC; TPMT Genotype; TPMT Phenotype
Formal name: Thiopurine S-methyltransferase Phenotype; Thiopurine S-methyltransferase Genotype

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NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used.

Sources Used in Current Review

Linnea Baudhuin, Phd, DABMG. Assistant Professor of Laboratory Medicine. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.

Nguyen et al. (May 15, 2011). Thiopurine methyltransferase (TPMT) genotyping to predict myelosuppression risk. PLoS Currents. Evidence on Genomic Tests. Available online at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094768/ through http://www.ncbi.nlm.nih.gov. Accessed March 2013.

(2013). Thiopurine Methyltransferase, Red Blood Cell. ARUP Laboratories. Available online at http://www.aruplab.com/guides/ug/tests/0092066.jsp through http://www.aruplab.com. Accessed March 2013.

(Updated Oct. 2011). TPMT Genotype. Quest Diagnostics.Available online at http://www.questdiagnostics.com/testcenter/testguide.action?dc=TS_TPMT_Genotype through http://www.questdiagnostics.com/. Accessed March 2013.

Azathioprine Metabolism and TPMT. Medscape. Availabe online at http://emedicine.medscape.com/article/1829596-overview through http://emedicine.medscape.com. Accessed March 2013.

(2003) Relling, M. Genetics and Anti-Leukemia Therapy: The TPMT Story. American Childhood Cancer Organization. Available online at http://www.acco.org/Information/tpmt.aspx through http://www.acco.org. Accessed April 2013.

Bruns D, Ashwood E, Burtis C, eds (2007). Fundamentals of Molecular Diagnostics, Saunders Elsevier, St. Lous, Missouri, Pp 200-203.

Sources Used in Previous Reviews

Dr. Jonathon Berg. City Hospital, Birmingham, England.

Clarke, W. and Dufour, D. R., Editors (2006). Contemporary Practice in Clinical Chemistry, AACC Press, Washington, DC. Pp. 479.

Wu, A. (2006). Tietz Clinical Guide to Laboratory Tests, Fourth Edition. Saunders Elsevier, St. Louis, Missouri. Pp. 1420.

(2008 July). Thiopurine Methyltransferase, Red Blood Cell. ARUP Laboratories Technical Bulletin [On-line information]. PDF available for download at http://www.aruplab.com/Testing-Information/resources/TechnicalBulletins/Thiopurine%20Methyltransferase,%20Red%20Blood%20Cell.pdf through http://www.aruplab.com. Accessed on 1/4/09.

Ansari, A.et. al (2008 December 17). Prospective Evaluation of the Pharmacogenetics of Azathioprine in the Treatment of Inflammatory Bowel Disease [On-line information]. Available online at http://www.medscape.com/viewarticle/584257 through http://www.medscape.com. Accessed on 1/4/09.

Aberra, F. and Lichtenstein, G. (Review Article: Monitoring of Immunomodulators in Inflammatory Bowel Disease. Medscape from Aliment Pharmacol Ther. 2005; 21 (4): 307-319. [On-line information]. Available online at http://www.medscape.com/viewarticle/499922_1 through http://www.medscape.com. Accessed on 1/4/09.

Derijks, L. et. al. (2006 September 26). Thiopurines in Inflammatory Bowel Disease. [On-line information]. Available online at http://www.medscape.com/viewarticle/543562 through http://www.medscape.com. Accessed on 1/4/09.

Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. Burtis CA, Ashwood ER and Bruns DE, eds. 4th ed. St. Louis, Missouri: Elsevier Saunders; 2006, Pg 1273.