A trypsinogen test sometimes is ordered when children or adults present with symptoms suggesting cystic fibrosis and pancreatic dysfunction such as persistent diarrhea, foul-smelling, bulky greasy stools, malnutrition, and vitamin deficiency.
Trypsinogen testing is non-diagnostic; there are a fair number of false positives and problems other than cystic fibrosis and pancreatic dysfunction that can cause a positive IRT. An elevated level must be followed with other testing. When diagnosing cystic fibrosis, this may include another IRT in a month, CF gene mutation testing, and/or sweat chloride testing.
IRT testing is only useful for the potential detection of cystic fibrosis. It will not identify carriers of CF; their trypsinogen production and function will not be affected. In those who do have CF, the degree of IRT elevation does not reflect the severity of the disease.
This article was last reviewed on December 11, 2012. | This article was last modified on June 10, 2014.
The review date indicates when the article was last reviewed from beginning to end to ensure that it reflects the most current science. A review may not require any modifications to the article, so the two dates may not always agree.
The modified date indicates that one or more changes were made to the article. Such changes may or may not result from a full review of the article, so the two dates may not always agree.