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Urine Metanephrines

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Also known as: Metanephrine and Normetanephrine
Formal name: Urine Metanephrines, Total and Fractionated

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NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used. To access online sources, copy and paste the URL into your browser.

Sources Used in Current Review

Blake, M. and Sweeney, A. (2014 June 16, Updated). Pheochromocytoma. Medscape Drugs & Diseases [On-line information]. Available online at http://emedicine.medscape.com/article/124059-overview. Accessed on 4/25/15.

Vuguin, P. (2013 June 27 Updated). Pediatric Pheochromocytoma. Medscape Drugs & Diseases [On-line information]. Available online at http://emedicine.medscape.com/article/988683-overview. Accessed 04/25/15.

Baldwin, E. et. al. (2015 April, Updated). Pheochromocytoma. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/Pheochromocytoma.html?client_ID=LTD. Accessed 4/25/15.

(© 1995–2015). Metanephrines, Fractionated, 24 Hour, Urine. Mayo Clinic Mayo Medical Laboratories [On-line information]. Available online at http://www.mayomedicallaboratories.com/test-catalog/Overview/83006. Accessed 04/25/15.

(2015 April 10, Updated). Unusual Cancers of Childhood Treatment (PDQ®). National Cancer Institute [On-line information]. Available online at http://www.cancer.gov/cancertopics/pdq/treatment/unusual-cancers-childhood/Patient/page7. Accessed 04/25/15.

Pagana, K. D., Pagana, T. J., and Pagana, T. N. (© 2015). Mosby's Diagnostic & Laboratory Test Reference 12th Edition: Mosby, Inc., Saint Louis, MO. Pp 973-976.

National Cancer Institute: PDQ® Pheochromocytoma and Paraganglioma Treatment. Bethesda, MD: National Cancer Institute. Date last modified 04/30/2015. Available online at http://www.cancer.gov/types/pheochromocytoma/hp/pheochromocytoma-treatment-pdq. Accessed 07/21/2105.

Lenders, J.W.M. et al. Guidelines on Pheochromocytoma and Paraganglioma. J Clin Endocrinol Metab, June 2014, 99(6): 1915-42.

Eisenhofer, G. and Peitzch, M. Laboratory Evaluation of Pheochromocytoma and Paraganglioma. Clinical Chemistry, 2014, 60(12) 1486–1499.

Sources Used in Previous Reviews
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Pagana, Kathleen D. & Pagana, Timothy J. (2001). Mosby's Diagnostic and Laboratory Test Reference 5th Edition: Mosby, Inc., Saint Louis, MO.

Sawka, A., et. al. (2003 February). A Comparison of Biochemical Tests for Pheochromocytoma: Measurement of Fractionated Plasma Metanephrines Compared with the Combination of 24-Hour Urinary Metanephrines and Catecholamines. The Journal of Clinical Endocrinology & Metabolism Vol. 88, No. 2 553-558 [On-line journal]. Available online at http://jcem.endojournals.org/cgi/content/full/88/2/553.

Brose, M. Updated (2004 August 3, Updated). Pheochromocytoma. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/000340.htm.

(© 2005). Metanephrines, Plasma. ARUP's Guide to Clinical Laboratory Testing [On-line information]. Available online at http://www.aruplab.com/guides/clt/tests/clt_a76b.jsp#2461156.

(© 2005). Metanephrines, Urine. ARUP's Guide to Clinical Laboratory Testing [On-line information]. Available online at http://www.aruplab.com/guides/clt/tests/clt_a77b.jsp#1141889.

(© 1995-2005). Pheochromocytoma. The Merck Manual of Diagnosis and Therapy, Section 2. Endocrine And Metabolic Disorders, Chapter 9. Adrenal Disorders [On-line information]. Available online at http://www.merck.com/mrkshared/mmanual/section2/chapter9/9d.jsp.

Vogin, G. Reviewed (2002). Plasma Metanephrines Best to Diagnose Pheochromocytoma. Medscape Medical News [On-line news article]. Available online at http://www.medscape.com/viewarticle/430266?src=search.

Schwartz, G. and Sheps, S. (2004 May 06). Hypertension. MedScape Today from ACP Medicine [On-line information]. Available online at http://www.medscape.com/viewarticle/474790?src=search.

(1998 May 27, Updated). Adrenal Medullary Hormones. Colorado State University, Hypertexts for Biological Sciences [On-line hypertextbook]. Available online at http://arbl.cvmbs.colostate.edu/hbooks/pathphys/endocrine/adrenal/medhormones.html.

Pagana, Kathleen D. & Pagana, Timothy J. (© 2007). Mosby's Diagnostic and Laboratory Test Reference. 8th Edition: Mosby, Inc., Saint Louis, MO. Pp 987-990.

Clarke, W. and Dufour, D. R., Editors (2006). Contemporary Practice in Clinical Chemistry. AACC Press, Washington, DC. Pp 382-383.

Wu, A. (2006). Tietz Clinical Guide to Laboratory Tests, Fourth Edition. Saunders Elsevier, St. Louis, Missouri. Pp 724-731.

Pacak, K. et. al. (2007 March 21). Pheochromocytoma: Recommendations for Clinical Practice from the First International Symposium. Medscape from Nat Clin Pract Endocrinol Metab. 2007;3(2):92-102. [On-line information]. Available online at http://www.medscape.com/viewarticle/553428. Accessed on 9/29/08.

Sweeney, A. et. al. (2007 September 11, Updated). Pheochromocytoma. EMedicine [On-line information]. Available online at http://www.emedicine.com/med/TOPIC1816.HTM. Accessed on 9/29/08.

Vilar, L. (2008 June 17). Adrenal Incidentalomas: Diagnostic Evaluation and Long-Term Follow-up. Medscape from Endocr Pract. 2008;14(3):269-278 [On-line information]. Available online at http://www.medscape.com/viewarticle/574415. Accessed on 9/29/08.

(2007 December). Pheochromocytoma. UrologyHealth.org [On-line information]. Available online at http://urologyhealth.org/adult/index.cfm?cat=02&topic=114. Accessed on 9/29/08.

Grossman, A. (2007 November Reviewed). Pheochromocytoma. Merck Manual for Professionals [On-line information]. Available online at http://www.merck.com/mmpe/print/sec12/ch153/ch153h.html. Accessed on 9/29/08.

Pagana, K. D. & Pagana, T. J. (© 2011). Mosby's Diagnostic and Laboratory Test Reference 10th Edition: Mosby, Inc., Saint Louis, MO. Pp 1023-1026.

(Reviewed 2011 January). Pheochromocytoma. American Urological Association AUA Foundation [On-line information]. Available online at http://www.urologyhealth.org/urology/index.cfm?article=14. Accessed December 2011.

(© 1995-2011). Test ID: METAR83005, Metanephrines, Fractionated, Random, Urine. Mayo Clinic Mayo Medical Laboratories [On-line information]. Available online at http://www.mayomedicallaboratories.com/test-catalog/Overview/83005. Accessed December 2011.

Blake, M. and Sweeney, A. (Updated 2011 October 19). Pheochromocytoma. Medscape Reference [On-line information]. Available online at http://emedicine.medscape.com/article/124059-overview. Accessed December 2011.

Frank, E. et. al. (Updated 2011 June). Pheochromocytoma. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/Pheochromocytoma.html?client_ID=LTD. Accessed December 2011.