Proceeds from website advertising help sustain Lab Tests Online. AACC is a not-for-profit organization and does not endorse non-AACC products and services.

Valproic Acid

Print this article
Share this page:
Also known as: Valproate; Free Valproic Acid [Often referred to by brand name (see MedlinePlus Drug Information)]
Formal name: Valproic Acid

Article Sources

« Return to Related Pages

NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used.

Sources Used in Current Review

Valproic Acid. Medline Plus. Available online at http://www.nlm.nih.gov/medlineplus/druginfo/meds/a682412.html. Last revised September 15, 2013. Accessed February 17, 2014.

Suzanne Bentley. Valproic Acid Level. Medscape. Available online at http://emedicine.medscape.com/article/2090462-overview through http://emedicine.medscape.com. Updated December 11, 2013. Accessed February 17, 2014.

Valproic Acid, Free and Total, Serum. Mayo Clinic. Available online at http://www.mayomedicallaboratories.com/test-catalog/Overview/81771 through http://www.mayomedicallaboratories.com. Accessed February 17, 2014.

Depaken. RxList.com. Available online at http://www.rxlist.com/depakene-drug.htm through http://www.rxlist.com. Last reviewed July 16, 2013. Accessed February 17, 2014.

Sources Used in Previous Reviews

Thomas, Clayton L., Editor (1997). Taber's Cyclopedic Medical Dictionary. F.A. Davis Company, Philadelphia, PA [18th Edition].

(© 2007). Valproic Acid. Epilepsy.com [On-line information]. Available online at http://www.epilepsy.com/medications/b_valproicacid_intro.html through http://www.epilepsy.com. Accessed on 4/1/07.

Waknine, Y. (2007 February 7). FDA Safety Changes: Kenalog-10 and Kanalog-40, Depacon, Depakene [On-line information]. Available online at http://www.medscape.com/viewarticle/551786 through http://www.medscape.com/viewarticle/551786. Accessed on 3/25/07.

Macritchie, KA (2006 October 1). Valproic acid, valproate and divalproex in the maintenance treatment of bipolar disorder. Medscape from Cochrane Rev Abstract [On-line information]. Available online at http://www.medscape.com/viewarticle/486474 through http://www.medscape.com. Accessed on 3/25/07.

Narayanaswamy, Sudha (2005 August, Updated). Depakote (vivalproex sodium) - Valproic Acid. NAMI [On-line information]. Available online through http://www.nami.org. Accessed on 3/25/07.

(2005 September). Depakene/Depakote/Depakote ER. Epilepsy Foundation [On-line information]. Available online at http://www.epilepsyfoundation.org/answerplace/Medical/treatment/medications/typesmedicine/depakote.cfm through http://www.epilepsyfoundation.org. Accessed on 3/31/07.

(2007 March 1). Valproic Acid (Oral Route, Parenteral Route). MayoClinic.com [On-line information]. Available online at http://www.mayoclinic.com/health/drug-information/DR602153 through http://www.mayoclinic.com. Accessed on 3/25/07.

(2005 August 10, Review). Seizures Emergencies Overview. eMedicineHealth [On-line information]. Available online at http://www.emedicinehealth.com/seizures_emergencies/article_em.htm through http://www.emedicinehealth.com. Accessed on 3/31/07.

(2006 October). Valproic Acid - Drug Review. Consumer Reports Medical Guide [On-line information]. Available online at http://www.consumerreports.org/mg/drug-reports/valproic-acid.htm through http://www.consumerreports.org. Accessed on 3/31/07.

(2004 April, Revision). Valproate, valproic acid, divalproex sodium. American Epilepsy Society [On-line information]. Available online at http://www.aesnet.org/Visitors/PatientsPractice/aed/aedtable.cfm?drug=Valproate%2C%20valproic%20acid%2C%20divalproex%20sodium through http://www.aesnet.org. Accessed on 4/1/07.

(2007 March 19, Updated). Seizures and Epilepsy: Hope Through Research. NINDS [On-line information]. Available online at http://www.ninds.nih.gov/disorders/epilepsy/detail_epilepsy.htm through http://www.ninds.nih.gov. Accessed on 3/31/07.

Clarke, W. and Dufour, D. R., Editors (2006). Contemporary Practice in Clinical Chemistry. AACC Press, Washington, DC. Harris, N. et. al. Chapter 39: Therapeutic Drug Monitoring. Pg 461.

Burtis C, Ashwood E, Bruns D, Eds. (2006). Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. Elsevier Saunders, St. Louis, Missouri. Pp 1253-1254.

Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL eds, (2005) Harrison's Principles of Internal Medicine, 16th Edition, McGraw Hill, Pp 2366-2368.

(October 10, 2009) American Cancer Society. Valproic Acid. Available online at http://www.cancer.org/Treatment/TreatmentsandSideEffects/GuidetoCancerDrugs/VALPROIC-ACID through http://www.cancer.org. Accessed January 2011.

Kidshealth. Blood test: Valproic Acid. Available online at http://kidshealth.org/parent/system/medical/test_valproic.html through http://kidshealth.org. Accessed January 2011.

(Updated November 4, 2010) Weigand T. Toxicity, Valproate. eMedicine online article. Available online at http://emedicine.medscape.com/article/819315-overview through http://emedicine.medscape.com. Accessed January 2011.

(June 28, 2010) McCall B. Valproate Carries Highest Risk for Major Congenital Malformations of All Anitepilieptics. Medscape Medical News. Available online at http://www.medscape.com/viewarticle/724671 through http://www.medscape.com. Accessed January 2011.

(December 3, 2009) Hitt E. FDA Reminds Healthcare Professionals of Valproate Link to Birth Defects. Medscape Medical News. Available online at http://www.medscape.com/viewarticle/713380 through http://www.medscape.com. Accessed January 2011.

Mayo Medical Laboratories. Valproic Acid, Free and Total, Serum. Available online at http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/81771 through http://www.mayomedicallaboratories.com. Accessed January 2011.

ARUP Laboratories. Valproic Acid, Free and Total. Available online at http://www.aruplab.com/guides/ug/tests/0099310.jsp through http://www.aruplab.com. Accessed January 2011.

(March 4, 2010) Glauser T. Ethosuxamide, Valproic Acid and Lamotrigine in Childhood Absence Epilepsy. N Engl J Med 2010; 362:790-799. Available online at http://www.nejm.org/doi/full/10.1056/NEJMoa0902014#t=articleTop through http://www.nejm.org. Accessed January 2011.

Narayanaswamy, Sudha (November 2010). Depakote (vivalproex sodium) – Valproic Acid. National Alliance on Mental Illness. Available online at http://www.nami.org/Template.cfm?Section=About_Medications&Template=/TaggedPage/TaggedPageDisplay.cfm&TPLID=51&ContentID=20823 through http://www.nami.org. Accessed January 2011.

(December 14 2010, Updated). Seizures and Epilepsy: Hope Through Research. NINDS [On-line information]. Available online at http://www.ninds.nih.gov/disorders/epilepsy/detail_epilepsy.htm through http://www.ninds.nih.gov. Accessed January 2011.