Increased levels of VLDL-C are thought to reflect the presence of particles called lipoprotein remnants that are intermediate particles on the pathway of conversion of VLDL to LDL. When high levels of VLDL are present, the conversion of VLDL to LDL is slowed and the accumulation of intermediate particles is thought to contribute to the development of atherosclerosis and coronary heart disease.
An elevated level of VLDL cholesterol (>30 mg/dL or >0.77 mmol/L), like elevated LDL cholesterol, is considered a risk factor for heart disease and stroke. The presence of high VLDL in addition to high LDL may affect the choice of therapy used to lower a person's cholesterol, such as lifestyle changes or drug treatment.
Low levels of VLDL cholesterol are not generally a concern.
VLDL cholesterol concentrations, like all lipoprotein fractions, can be measured directly using techniques such as lipoprotein electrophoresis and ultracentrifugation. However, these techniques are complex and expensive and are not usually done in clinical laboratories. These tests are generally carried out in specialty laboratories, most often for research purposes.
This article was last reviewed on September 30, 2013. | This article was last modified on November 15, 2013.
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