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Treatment depends on the underlying cause of the jaundice. In newborns, phototherapy (special light therapy), blood exchange transfusion in severe cases, and certain drugs may reduce the bilirubin level. In Gilbert, Rotor, and Dubin-Johnson syndromes, no treatment is usually necessary. Crigler-Najjar syndrome may respond to certain enzyme drug therapies or may require a liver transplant or blood transfusion. Jaundice caused by obstruction of the bile ducts is often resolved by surgery to remove the blockage. Cirrhosis-caused jaundice is a result of long-term liver damage and does not respond well to any type of therapy other than a liver transplant.

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