Proceeds from website advertising help sustain Lab Tests Online. AACC is a not-for-profit organization and does not endorse non-AACC products and services.


Print this article
Share this page:


The following table illustrates the two most commonly used classifications plus an older classification. Because of differences in how the lymphomas are described, there is not a one-to-one comparison between the systems, and a single disease could be known by multiple names.

Comparison of Some Non-Hodgkin Lymphoma Classifications

Note: These classifications cannot always be compared.
NCI* (Working   Formulation) (Older Classification)REAL**WHO*** Classification
  B cell lineage/NHL Mature B cell lymphoma
Low grade lymphoma
Small lymphocytic lymphoma (plasmacytoid)




Follicular lymphoma (small cleaved cell, large cell, mixed cell)        

High Grade lymphoma
Diffuse lymphoma (small  cleaved, large, mixed cell)
Diffuse immunoloblastic lymphoma 
Burkitt Lymphoma
Burkitt-like Lymphoma Lymphoblastic lymphoma

B-cell chronic lymphocytic leukemia      

Lymphoplasmacytic lymphoma    

Nodal and extranodal marginal B-cell lymphoma                

Follicular Center, grades I, II, and III lymphoma 

Mantle Cell lymphoma

B cell CLL / SLL 

Splenic marginal zone B-cell lymphoma

Extranodal marginal B cell lymphoma (MALT lymphoma)  

Nodal marginal zone lymphoma

Follicular lymphoma

Lymphoplasmacytic lymphoma                       

Mantle cell lymphoma 

Diffuse large B-cell lymphoma, not otherwise specified

Diffuse large B-cell lymphoma of various subtypes        

Burkitt lymphoma

T and NK Cell Neoplasms   T and NK Cell Neoplasms
    Peripheral T-cell lymphoma, not otherwise specified

Small lymphocyte lymphoma

Mycosis Fungoides

Diffuse lymphoma (small cleaved, large, mixed cell) 

Large cell immunoblastic lymphoma


Adult T-cell leukemia/lymphoma    

Extranodal NK/T-cell lymphoma, nasal type

Enteropathy-associated T-cell lymphoma

Subcutaneous panniculitis-like T-cell lymphoma

Mycosis fungoides

Primary cutaneous CD30-positive T-cell lymphoproliferative disorders

Anaplastic large cell  lymphoma (ALK-positive or ALK-negative) 

Angioimmunublastic T-cell lymphoma


Histiocytic sarcoma

Langerhans cell histiocytosis

Langerhans cell sarcoma

Interdigitating dendritic cell sarcoma/tumor

Follicular dendritic cell sarcoma/tumor

Dendritic cell sarcoma, not otherwise specified

* NCI = National Cancer Institute
** REAL = Revised European American Lymphoma
*** WHO = World Health Organization

« Prev | Next »