Treatment of reactive arthritis involves treating any underlying infection with antibiotics and use of medications such as ibuprofen and acetaminophen to relieve symptoms.
Inflamed joints can be injected with corticosteroids or occasionally the fluid can be drained. If the disease is severe and lasts over a couple of months, use of disease modifying anti-rheumatic drugs (DMARDs) such as sulfasalazine and methotrexate may be considered. Tumor necrosis factor (TNF) inhibitors may also be effective.
Topical corticosteroids may be useful for treating skin lesions.
Often, rest is required initially to control the pain, and physical therapy is also used to maintain a full range of movement of joints.