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Putting New Laboratory Tests into Practice

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Putting Laboratory Tests into Practice: Part I II III IV V

NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used. To access online sources, copy and paste the URL into your browser.

Sources Used in Current Review

Medicare.gov. Your Medicare Coverage. Available online at https://www.medicare.gov/coverage/clinical-lab-services.html. Accessed October 2016.

(May 24, 2016) Centers for Medicare and Medicaid Services. Regulation and Guidance, Clinical Laboratory Improvement Amendments (CLIA). Available online at https://www.cms.gov/Regulations-and-Guidance/Legislation/CLIA/index.html. Accessed October 2016.

©2016 ABIM Foundation. Choosing Wisely. Available online at http://www.choosingwisely.org/. Accessed October 2016.

©2016 AvaMedDx. Our Industry and Technology, Uses of Diagnostic Tests. Available online at http://dx.advamed.org/diagnostics-policy/our-industry-technology-0. Accessed October 2016.

(June 4, 2016) U.S. Food and Drug Administration. Humanitarian Device Exemption. Available online at http://www.fda.gov/MedicalDevices/DeviceRegulationandGuidance/HowtoMarketYourDevice/PremarketSubmissions/HumanitarianDeviceExemption/default.htm. Accessed October 2016.

(August 6, 2014) U.S. Food and Drug Administration. HDE Approvals. Available online at http://www.fda.gov/MedicalDevices/ProductsandMedicalProcedures/DeviceApprovalsandClearances/HDEApprovals/default.htm. Accessed October 2016.

(June 4, 2016) U.S. Food and Drug Administration. Listing of CDRH Humanitarian Device Exemptions. Available online at http://www.fda.gov/MedicalDevices/ProductsandMedicalProcedures/DeviceApprovalsandClearances/HDEApprovals/ucm161827.htm. Accessed October 2016.

(March 17, 2014) Gaffney A. Regulatory Explainer: Making Sense of Humanitarian Use Devices. Available online at http://www.raps.org/focus-online/news/news-article-view/article/4775/. Accessed October 2016.

The Free Dictionary. Class III device. Available online at http://medical-dictionary.thefreedictionary.com/class+III+device. Accessed October 2016.

(January-February 2006) Food and Drug Administration. Medical Device and Radiological Health Regulations Come of Age. Available online at http://www.fda.gov/aboutfda/whatwedo/history/productregulation/medicaldeviceandradiologicalhealthregulationscomeofage/default.htm. Accessed October 2016.

Congress.gov. H.R.3095 - Safe Medical Devices Act of 1990. Available online at https://www.congress.gov/bill/101st-congress/house-bill/3095. Accessed October 2016.

Food and Drug Administration. December 2014 PMA Approvals. Available online at http://www.fda.gov/MedicalDevices/ProductsandMedicalProcedures/DeviceApprovalsandClearances/PMAApprovals/ucm439050.htm. Accessed October 2016.

University of California San Francisco. Information sheet for clinical laboratory testing. Available online at https://accelerate.ucsf.edu/research/clinical-laboratory-testing. Accessed October 2016.

Centers for Disease Control and Prevention. Clinical Laboratory Improvement Amendments. Available online at https://wwwn.cdc.gov/clia/Resources/TestComplexities.aspx. Accessed October 2016.

Food and Drug Administration. CLIA categorizations. Available online at http://www.fda.gov/medicaldevices/deviceregulationandguidance/ivdregulatoryassistance/ucm393229.htm. Accessed October 2016.

HHS, Medicare Learning Network. The Clinical Laboratory Improvement Amendments (CLIA). Available online at https://www.cms.gov/Outreach-and-Education/Medicare-Learning-Network-MLN/MLNProducts/Downloads/CLIABrochure.pdf. Accessed October 2016.

Food and Drug Administration, PMA Monthly approvals from 6/1/2016 to 6/30/2016 http://www.fda.gov/downloads/MedicalDevices/ProductsandMedicalProcedures/DeviceApprovalsandClearances/PMAApprovals/UCM510219.pdf Accessed October 2016.

(November 17, 2015) Jeffrey E. Shuren M.D., J.D. Director, Center for Devices and Radiological Health, U.S. Department of Health and Human Services. Food and Drug Administration, Statement on Examining the Regulation of Diagnostic Tests and Laboratory Operations before Committee on Energy and Commerce Subcommittee on Health. Available online at http://www.hhs.gov/asl/testify/2015/11/t20151117a.html. Accessed October 2016.

(June 4, 2014) U.S. Food and Drug Administration. Learn if a Medical Device Has Been Cleared by FDA for Marketing. Available online at http://www.fda.gov/MedicalDevices/ResourcesforYou/Consumers/ucm142523.htm. Accessed October 2016.

(October 3, 2016) U.S. Food and Drug Administration. Medical Device Exemptions 510(k) and GMP Requirements. Available online at http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfpcd/315.cfm. Accessed October 2016.

Encyclopedia.com. Genetic testing. Available online at http://www.encyclopedia.com/topic/Genetic_Testing.aspx. Accessed October 2016.

(April 21, 2016) CLN Stat. Who should regulate LDTs? Available online at https://www.aacc.org/publications/cln/cln-stat/2016/april/21/who-should-regulate-ldts. Accessed October 2016.

Food and Drug Administration. The Public Health Evidence for FDA Oversight of Laboratory Developed Tests: 20 Case Studies Available online at http://www.fda.gov/AboutFDA/ReportsManualsForms/Reports/ucm472773.htm. Accessed October 2016.

Food and Drug Administration. Laboratory Developed Tests. Available online at http://www.fda.gov/MedicalDevices/ProductsandMedicalProcedures/InVitroDiagnostics/ucm407296.htm. Accessed October 2016.

National Independent Laboratory Association. Press release: Members of Congress Approve Language to Delay FDA Oversight of LDTs. Available online at http://www.nila-usa.org/nila/Members_of_Congress_Approve_Language__To_Delay_FDA.asp. Accessed October 2016.

Sources Used in Previous Reviews

The original article was written by Cathy Tokarski with additional contributions from:

Fred Lasky, PhD, formerly Director of Diagnostics Compliance for Ortho-Clinical Diagnostics, a division of Johnson & Johnson, Rochester, NY.

Robert Murray, PhD, formerly Technical Director for Midwest Diagnostic Pathology at Lutheran General Hospital, Park Ridge, IL.

Sue Evans PhD, formerly Vice President of Product Development for Caliper Technologies Corporation.

Steven Gutman, MD, formerly Director - Division of Clinical Laboratory Devices, US Food and Drug Administration.

David Sundwall, formerly President of the American Clinical Laboratory Association.

Elissa Passiment, EdM, CLS(NCA), Executive Vice President,of the American Society for Clinical Laboratory Science.

US Food and Drug Administration: Premarket Approval Applications for In Vitro Diagnostic Devices Pertaining to Hepatitis C Viruses; CDRH Consumer Information, Learn if a Medical Device Has Been Cleared by FDA for Marketing; Device Advice, Class I/II Exemptions. Available online through http://www.fda.gov.

CLIA Regulations. Subpart K, Sec. 493.1253. Available online at http://wwwn.cdc.gov/clia/regs/subpart_k.aspx#493.1250 and Subpart E available online at http://wwwn.cdc.gov/clia/regs/subpart_e.aspx. Accessed August 2009.

American Association for Clinical Chemistry Resource Library. Genetic and Laboratory-Developed Tests. Available online at http://www.aacc.org/resourcecenters/resource_topics/tests/Pages/default.aspx. Accessed August 2009.

U.S. Food and Drug Administration. Draft Guidance for Industry, Clinical Laboratories and FDA Staff. In Vitro Diagnostic Multivariate Index Assays, Issued July 26, 2007. Available online at http://www.fda.gov/MedicalDevices/DeviceRegulationandGuidance/GuidanceDocuments/ucm079148.htm. Accessed August 2009.

College of American Pathologists. About the CAP Accreditation Program. Available online at http://www.cap.org/apps/cap.portal?_nfpb=true&_pageLabel=accreditation. Accessed August 2009.

Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. Burtis CA, Ashwood ER and Bruns DE, eds. 4th ed. St. Louis, Missouri: Elsevier Saunders; 2006 Pp 353-356.

Clarke, W. and Dufour, D. R., Editors (2006). Contemporary Practice in Clinical Chemistry, AACC Press, Washington, DC, Pp 51-60.

U.S. Food and Drug Administration. Medical Devices, Device Advice: Device Regulation and Guidance, Overview (Updated August 31, 2009). Available online at http://www.fda.gov/MedicalDevices/DeviceRegulationandGuidance/Overview/default.htm. Accessed September 2009.

U.S. Food and Drug Administration, Center for Devices and Radiological Health (June 30, 2009 Updated). New Humanitarian Device Approval: Mesomark ™ - H060004. Available online at http://www.fda.gov/MedicalDevices/ProductsandMedicalProcedures/DeviceApprovalsandClearances/Recently-ApprovedDevices/ucm077034.htm. Accessed August 2009.

U.S. Food and Drug Administration, Center for Devices and Radiological Health Guidance for Industry and FDA Staff: Humanitarian Device Exemption (HDE) Regulation: Questions and Answers (July 18, 2006, Issued). Available online at http://www.fda.gov/MedicalDevices/DeviceRegulationandGuidance/GuidanceDocuments/ucm071473.htm. Accessed August 2009.

National Cancer Institute. Mesothelioma: Questions and Answers. Available online at http://www.cancer.gov/cancertopics/factsheet/sites-types/mesothelioma. Accessed August 2009.

Hammerschmidt, D. Humanitarian Use Devices: A Brief Guide for Clinicians, Investigators, and IRB Members (October 2002, issued). PDF available for download at http://www.research.umn.edu/irb/members/education/HUDs.pdf. Accessed August 2009.

Fujirebio Diagnostics. Managing Mesothelioma. Available online at http://www.fdi.com/mesomark/world/patients/managing_mesothelioma.html. Accessed August 2009.

Pacific Hearth & Blood Institute. Mesomark. (Dec 12, 2008). Available online at http://www.phlbi.org/phlbi/mesomark-blood-test-may-help-doctors-measure-a-patients-response-to-therapy/. Accessed August 2009.

(September 9, 2007) Clinical Trials.gov. Understanding Clinical Trials. Available online at http://www.clinicaltrials.gov/ct2/info/understand. Accessed August 2009.

Clinical Laboratory Standards Institute. About CLSI (2009), Frequently Asked Questions. Available online at http://www.clsi.org/Content/NavigationMenu/AboutCLSI/FAQ/FAQ.htm. Accessed August 2009.

US Department of Health and Human Services. Centers for Medicare and Medicaid Services. Accrediting Organizations/Exempt States. Available online at https://www.cms.hhs.gov/CLIA/13_Accreditation_Organizations_and_Exempt_States.asp#TopOfPage. Accessed September 2009.

College of American Pathologists. Accreditation and Laboratory Improvement. Available online at http://www.cap.org/apps/cap.portal?_nfpb=true&_pageLabel=accreditation. Accessed August 2009.

The Joint Commission. Accreditation, Laboratory Services. Available online at http://www.jointcommission.org/AccreditationPrograms/LaboratoryServices/HTBA/. Accessed August 2009.

National Human Genome Research Institute. Promoting Safe and Effective Genetic Testing In the United States (April 2006). Available online at http://www.genome.gov/10002393. Accessed August 2009.

US Food and Drug Administration. Medical Devices, Learn if a Medical Device Has been Cleared by the FDA for Marketing (June 18, 2009). Available online at http://www.fda.gov/MedicalDevices/ResourcesforYou/Consumers/ucm142523.htm. Accessed August 2009.

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