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Screening Tests for Adults (Ages 30-49)

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Not everyone in this age group may need screening for every condition listed here. Click on the links above to read more about each condition and to determine if screening may be appropriate for you or your family member. You should discuss screening options with your health care practitioner.

High Cholesterol

Beginning in childhood, the waxy substance called cholesterol and other fatty substances known as lipids start to build up in the arteries, hardening into plaques that narrow the passageway. During adulthood, plaque buildup and resulting health problems occur not only in arteries supplying blood to the heart muscle but in arteries throughout the body (a problem known as atherosclerosis). For both men and women in the United States, the number one cause of death is heart disease, and the amount of cholesterol in the blood greatly affects a person's chances of suffering from it.

Screening for high cholesterol, specifically high LDL cholesterol (the "bad" cholesterol), is important because it may not cause any symptoms and yet, according to the Centers for Disease Control and Prevention (CDC), two out of three adults have it.


The National Cholesterol Education Program (NCEP) and the American Heart Association (AHA) recommend:

  • Every 5 years, all adults 20 years of age and older should have a complete, fasting lipid profile.

If you fast for 9 to 12 hours before taking this blood test, the test provides 4 measurements: 1) total cholesterol, 2) LDL cholesterol, which you want to be low because it contributes to buildup and blockage, 3) HDL cholesterol, which you want to be high, and 4) triglycerides, which are another form of fat in your blood. This fasting test is the preferred initial test, according to the NCEP. Without fasting, two useful measurements can be obtained: total cholesterol and HDL cholesterol.

  • If one or more of the following applies to you as a young adult, you may need more frequent testing:
    • Your total cholesterol result is 200 mg/dL or higher
    • You are a man over the age of 45 or a woman over the age of 50-55
    • Your HDL cholesterol is under 40 mg/dL
    • You have other risk factors for heart disease and stroke

The U.S. Preventive Services Task Force (USPSTF) recommends screening for high cholesterol as follows:

  • For men aged 20 to 35: if they are at increased risk for coronary heart disease; it strongly recommends screening men aged 35 and older, regardless of risk factors.
  • For women aged 20 to 45: if they are at increased risk for coronary heart disease; it strongly recommends screening women aged 45 and older if they are at increased risk for coronary heart disease.

Risk Factors

You also are more vulnerable and would want more frequent testing if you have any known risk factors, such as:

  • Smoking
  • Hypertension (blood pressure of 140/90 mm Hg or higher, or you take antihypertensive medications)
  • Diabetes
  • Obesity or overweight
  • Physical inactivity
  • Family history of early heart disease

Men have greater risk for heart attack than women, and risk for heart disease increases with age.

University of Maryland Heart Center: Heart Disease Risk Calculator
National Heart, Lung, and Blood Institute: What is Cholesterol?

Sources Used in Current Review

Centers for Disease Control and Prevention. FASTSTATS – Leading Causes of Death (2009 data). Available online at through Accessed October 2012.

Centers for Disease Control and Prevention. National Cholesterol Education Month. Page last updated: September 10, 2012. Available online at through Accessed October 2012.

American Heart Association. How To Get Your Cholesterol Tested. Updated June 14, 2012. Available online through Accessed October 2012. 

American Heart Association. Understand Your Risk of Heart Attack. Available online through Accessed October 2012.

National Cholesterol Education Program (NCEP) guidelines for a cholesterol test: Healthwise Medical Information on eMedicineHealth. Available online at through Accessed October 2012.

U.S. Preventive Services Task Force. Screening for Lipid Disorders in Adults. Release Date: June 2008. Available online at Accessed October 2012.