ApoE Genotyping

Also known as: ApoE cardiac risk; ApoE 2 mutations; APOE4 genotype

Formal name: Apolipoprotein E genotyping

At a Glance

Why Get Tested?

Apo E genotyping is not widely used. The clinical usefulness of this test is still being researched. However, it may be used in two different conditions:

For cardiovascular risk assessment, to help make treatment decisions for individuals with cardiovascular disease or to help confirm a diagnosis of Type III hyperlipoproteinemia (also known as familial dysbetalipoproteinemia)
As an aid in the diagnosis of probable late onset Alzheimer's disease in a symptomatic adult

When to Get Tested?

When your doctor suspects that you have an inherited component to your high cholesterol and triglyceride levels or if you have yellowish lesions called xanthomas on your skin
When you have progressive symptoms of dementia and your doctor wants to determine the likelihood that this is due to Alzheimer’s disease

Sample Required?

A blood sample drawn from a vein in your arm

Test Preparation Needed?

None