Peritoneal Fluid Analysis

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Formal name: Peritoneal Fluid Analysis

At a Glance

Why Get Tested?

To help diagnose the cause of peritonitis and/or peritoneal fluid accumulation (called ascites)

When to Get Tested?

When a doctor suspects that someone with abdominal pain and swelling, nausea, and/or fever has a condition associated with inflammation of the peritoneum (peritonitis) or peritoneal fluid accumulation

Sample Required?

A peritoneal fluid sample obtained by inserting a needle into the abdominal cavity

Test Preparation Needed?

You will be asked to empty your bladder prior to sample collection.

The Test Sample

What is being tested?

Peritoneal fluid is a liquid that acts as a lubricant in the abdominal cavity. It is found in small quantities between the layers of the peritoneum. Produced by mesothelial cells in the abdominal membranes, peritoneal fluid acts to moisten the outside of the organs and to reduce the friction of organ movement during digestion.

A variety of conditions and diseases can cause inflammation of the peritoneum (peritonitis) and/or excessive accumulation of peritoneal fluid (peritoneal effusion or ascites). Peritoneal fluid analysis is a group of tests that evaluate this liquid to determine the cause of the increased fluid.

The two main reasons that fluid may collect in the abdominal cavity are:

  • An imbalance between the pressure within blood vessels—which drives fluid out of blood vessels—and the amount of protein in blood—which keeps fluid in blood vessels. The fluid that accumulates in this case is called a transudate. Transudates are most often caused by congestive heart failure or cirrhosis.
  • An injury or inflammation of the peritoneum, in which case the fluid is called an exudate. This type of fluid may be the result of conditions such as infection, malignancies (metastatic cancer, lymphoma, mesothelioma), or autoimmune disease.

Differentiation between the types of fluid is important because it helps diagnose the likely cause of fluid accumulation. Doctors and laboratorians use an initial set of tests (cell count, albumin level, and appearance of the fluid) to distinguish between transudates and exudates. Once the fluid is determined to be one or the other, additional tests may be performed to further pinpoint the disease or condition causing ascites.

How is the sample collected for testing?

A sample of peritoneal fluid is collected by a doctor with a syringe and needle using a procedure called paracentesis.

NOTE: If undergoing medical tests makes you or someone you care for anxious, embarrassed, or even difficult to manage, you might consider reading one or more of the following articles: Coping with Test Pain, Discomfort, and Anxiety, Tips on Blood Testing, Tips to Help Children through Their Medical Tests, and Tips to Help the Elderly through Their Medical Tests.

Another article, Follow That Sample, provides a glimpse at the collection and processing of a blood sample and throat culture.

Is any test preparation needed to ensure the quality of the sample?

You will be asked to empty your bladder prior to sample collection.

The Test

Common Questions

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Article Sources

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NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used.

Sources Used in Current Review

Shlamovitz, G. and Shah, N. (Updated 2012 May 9). Paracentesis. Medscape Reference. [On-line information]. Available online at http://emedicine.medscape.com/article/80944-overview through http://emedicine.medscape.com. Accessed June 2012.

Dugdale, D. (Updated 2011 February 4). Peritoneal fluid analysis. MedlinePlus Medical Encyclopedia. [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003626.htm. Accessed June 2012.

Daley, B. et. al. (Updated 2011 March 29). Peritonitis and Abdominal Sepsis. Medscape Reference [On-line information]. Available online at http://emedicine.medscape.com/article/180234-overview through http://emedicine.medscape.com. Accessed June 2012.

Zieve, D. (2011 October 16). Ascites. MedlinePlus Medical Encyclopedia . [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/000286.htm. Accessed June 2012.

Wolf, D. and Raghuraman, U. (Updated 2011 March 21). Chylous Ascites. Medscape Reference. [On-line information]. Available online at http://emedicine.medscape.com/article/185777-overview#showall through http://emedicine.medscape.com. Accessed June 2012.

Herrine, S. (Revised 2009 July). Ascites. Merck Manual for Healthcare Professionals. [On-line information]. Available online through http://www.merckmanuals.com. Accessed June 2012.

Sources Used in Previous Reviews

Pagana, Kathleen D. & Pagana, Timothy J. (© 2007). Mosby's Diagnostic and Laboratory Test Reference 8th Edition: Mosby, Inc., Saint Louis, MO. Pp 694-699.

Wu, A. (2006). Tietz Clinical Guide to Laboratory Tests, Fourth Edition. Saunders Elsevier, St. Louis, Missouri. Pp 1535-1536.

Thomas, Clayton L., Editor (1997). Taber's Cyclopedic Medical Dictionary. F.A. Davis Company, Philadelphia, PA [18th Edition]. Pp 1448-1449.

Forbes, B. et. al. (© 2007). Bailey & Scott's Diagnostic Microbiology, Twelfth Edition: Mosby Elsevier Press, St. Louis, Missouri. Pp 904 – 913.

Van Voorhees, B. (2007 January 22, Updated). Peritoneal fluid analysis. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003626.htm. Accessed on 6/21/08.

Lehrer, J. (2006 November 14, Updated). Peritonitis – spontaneous. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/000648.htm. Accessed on 6/21/08.

(2002 May 13). National Cancer Institute. Mesothelioma: Questions and Answers [On-line information]. Available online at http://www.cancer.gov/cancertopics/factsheet/sites-types/mesothelioma through http://www.cancer.gov. Accessed on 7/3/08.

(2008 March 22, Updated). ACS. Malignant Mesothelioma Detailed Guide [On-line information]. Available online at http://www.cancer.org/docroot/CRI/content/CRI_2_4_7x_CRC_Malignant_Mesothelioma_PDF.asp through http://www.cancer.org. Accessed on 7/3/08.

Carl Kjeldsberg and Joseph Knight. Body Fluids. Third edition. ASCP Press. Pp. 223-253.