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This article waslast modified on
October 28, 2017.
What is malabsorption?

Malabsorption is a condition caused by the decreased ability to digest and/or absorb nutrients from food. It is seen with a variety of diseases and can lead to general malnutrition or to symptoms associated with deficiencies in specific nutrients.

The body requires a steady supply of nutrients to build, repair, and maintain itself, to produce energy, enzymes, hormones, proteins, cells, tissues and bone, and to fight infections. Nutrients come from the diet and include many essential vitamins and minerals (micronutrients).

Food that is eaten is digested in three stages:

  • Proteins, fats, and complex sugars (carbohydrates) are broken down by stomach acids, enzymes produced by the pancreas, and bile from the liver. This process also releases micronutrients.
  • Nutrients are absorbed primarily by cells in the small intestines.
  • Nutrients are transported throughout the body and used or stored.

Any disruption or interference with this process can lead to malabsorption. The type and severity of deficiencies seen and the symptoms experienced depend on whether the problem affects general digestion and absorption or affects one or more specific nutrient.

Digestive problems
Fat, proteins and carbohydrates cannot be properly digested without bile and pancreatic enzymes. Insufficiencies in these substances can occur, for example, with liver and pancreatic diseases that limit their production, and with conditions such as cystic fibrosis that prevent pancreatic enzymes from getting to the digestive tract.

Absorption problems
If the intestines are unable to or prevented from absorbing nutrients, then the nutrients are eliminated from the body in the stool. This can happen when there is damage to the intestinal cells and tissues or when the intestines have been shortened, such as due to surgery, reducing the surface area and the amount of time available in which nutrients can be absorbed from food as it passes through the digestive tract.

As an example of a specific deficiency, vitamin B12 absorption requires both stomach acid and intrinsic factor, a substance produced by parietal cells in the stomach. Stomach acid separates B12 from proteins and intrinsic factor binds with B12. A lack of either one prevents intestinal absorption and can lead to vitamin B12 deficiency. This can happen with advancing age, with medications that suppress stomach acid production, with gastric bypass surgeries, and with diseases that damage parietal cells or cause general malabsorption.

Transport problems
Once absorbed in the intestines, nutrients may be hindered from being transported throughout the body. This may be caused by problems with the lymphatic system such as lymphoma or the rare inherited disorder, abetalipoproteinemia.

Accordion Title
About Malabsorption
  • Causes of Malabsorption

    There are a number of conditions and diseases that can cause malabsorption. Below is a list of just some of these:

    • Narrowing, closure or absence of bile ducts (biliary atresia) or blockage of bile flow (cholestasis) causing a lack of bile for digestion
    • Cancers, including pancreatic cancer, lymphoma, stomach cancer
    • Celiac disease—an autoimmune disease that causes damage to the lining of the intestines (intestinal villi)
    • Cystic fibrosis—a genetic condition that affects the pancreas and the transportation of pancreatic enzymes to the site of digestion
    • Damage to the intestines, such as from radiation treatment
    • Decreased intrinsic factor production
    • Diseases that affect circulation, such as congestive heart failure
    • Food intolerances, such as lactose intolerance, and enzyme deficiencies
    • AIDS
    • Hyperthyroidism
    • Infections of the digestive tract, including viral, bacterial and parasitic infections
    • Inflammatory bowel disease (Crohn disease and ulcerative colitis)
    • Liver diseases
    • Medications, such as phenytoin and those that inhibit stomach acid production
    • Pancreatic diseases and pancreatic insufficiency—can cause decreased amounts of pancreatic enzymes
    • Scleroderma
    • Surgery, such as a bowel resection or gastric bypass
    • Zollinger-Ellison syndrome—a rare condition causing tumors in the pancreas and/or intestines
  • Signs and Symptoms

    The signs and symptoms of malabsorption depend upon the underlying cause as well as the type and severity of nutrient deficiencies. They may become evident quickly or develop slowly and worsen over time. Some nutrients, such as vitamin B12, are stored by the body and symptoms only emerge when stores become depleted. Symptoms associated with insufficient pancreatic enzymes may not emerge until about 90% of the body's production capacity is disrupted.

    Some of the most common signs and symptoms seen with general malabsorption include:

    • Persistent diarrhea
    • Fatty stools that are loose and foul-smelling (steatorrhea)
    • Failure to thrive (in children)
    • Abdominal pain, cramps, bloating, and gas


    Other signs and symptoms may be due to general ill health or to specific deficiencies caused by malabsorption. They may include:

    • Weakness, fatigue
    • Fluid build-up in the abdomen (ascites)
    • Dry and scaly skin, rash
    • Inflammation of tongue (glossitis)
    • Muscle wasting, unexplained weight loss
    • Nausea and vomiting
    • Swelling of the hands, feet and legs (peripheral edema)
    • Inflammation of mouth (stomatitis)
    • Easy bruising, bleeding gums
    • Numbness and tingling in feet and hands
    • Paleness
    • Muscle or bone pain


    The following are some complications that can develop over time as a result of chronic malabsorption:

  • Tests

    The purpose of testing may be to:

    • Screen those at risk for malabsorption because of an underlying condition such as cystic fibrosis

    • Detect malabsorption, identify its underlying cause(s), and evaluate the types and severity of nutrient deficiencies present

    • Detect complications such as anemia

    • Monitor the effectiveness of treatment in people with malabsorption


    There is no single test that can identify malabsorption or the underlying cause. Typically, a healthcare practitioner will take into account many factors when ordering tests, including results from a physical examination, family history, medical history, and signs and symptoms. Testing will often be performed in steps with results leading toward a diagnosis while ruling out other possible causes. Testing typically involves ordering:

    • An initial set of general tests that evaluate body organs, cells, and digestion and that look for a cause for a person's persistent diarrhea, one of the most common symptoms of malabsorption

    • Specific follow-up tests that are used to detect or exclude diseases associated with malabsorption and to identify specific deficiencies and/or complications


    Laboratory Tests

    Initial testing may include:


    Based upon initial testing results, the person's symptoms, and the healthcare practitioner's suspicions, follow-up testing may include one or more of the following:


    Tests sometimes ordered include:


    Non-Laboratory Tests

    Testing to examine the digestive tract, liver, and/or pancreas is sometimes necessary and may include:

    • Abdominal ultrasound
    • CT scan
    • Endoscopy
    • Endoscopic retrograde pancreatography (ERCP)


    Learn more about these imaging procedures at RadiologyInfo.org.

  • Treatment

    A person affected by malabsorption can work with their healthcare provider, a nutritionist, or other healthcare professionals to address and manage their condition. Treatment of malabsorption typically includes one or more of the following:

    • Addressing the underlying cause to the extent possible to minimize malabsorption symptoms and intestinal damage
    • Replacing missing nutrients; this may include the use of oral pancreatic enzyme supplements and the replacement of minerals and vitamins A, D, E, and K, vitamin B12 and folate, etc.
    • Making nutrient-rich foods available; for some people, a low-fat, high-protein diet may be recommended; for others, significant diet alterations, such as a gluten-free diet, may be necessary.
    • Working with a healthcare practitioner to develop a treatment plan that is tailored to an individual person's clinical situation
    • Monitoring the person's health status over time; this often involves performing laboratory tests such as a complete blood count (CBC) or comprehensive metabolic panel (CMP) at regular intervals.
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