Food Sensitivity Test
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What Is Food Sensitivity?
Food sensitivities and intolerances are unwanted reactions to certain foods. Consuming these foods can cause various symptoms including upset stomach, bloating, and other gastrointestinal problems.
Food sensitivities and intolerances are not the same as food allergies. The central difference is that true allergies are caused by an overreaction of the immune system.
With food sensitivities and intolerances, reactions are normally predictable and increase based on how much of the food is consumed. In contrast, allergic reactions can have unpredictable severity and often occur with minuscule levels of exposure or even just contact with the skin.
Examples of food sensitivities and intolerances include:
- Lactose intolerance
- Non-celiac gluten sensitivity
- Caffeine intolerance
- Alcohol sensitivity
- Intolerance to food additives like sulfites
- Intolerance to FODMAPs (fermentable oligosaccharides, disaccharides, monosaccharides, and polyols)
The Role of Food Sensitivity Testing
Testing for food sensitivities is done after a person has had symptoms of an adverse food reaction. Based on the symptoms and the foods consumed before they occurred, tests can be ordered to look for specific food allergies, intolerances, or sensitivities. In this way, food sensitivity testing is a tool for diagnosis, helping to identify foods that provoke an abnormal reaction.
It is uncommon to do broad screening for food sensitivities, especially if you haven’t already had signs or symptoms of a food reaction.
Who should get testing?
It is generally recommended to only test for food sensitivities or intolerances after you have experienced symptoms of a potential problem.
If you haven’t had symptoms, food sensitivity testing is likely to have more downsides than benefits. No test exists that can accurately detect all food sensitivities. Testing for a wide range of possible reactions can return a false positive, which means the test shows an intolerance or sensitivity for a food that doesn’t actually cause you problems. False positives can cause unnecessary changes to your diet that may affect your nutrition.
If you’ve had signs of a food reaction, talk with your doctor. By reviewing your experience and symptoms, the doctor can describe the pros and cons of testing for specific allergens, intolerances, and/or sensitivities.
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Types of Food Sensitivity Tests
No single, comprehensive test is available to check for all or even most types of food sensitivities. As a result, tests are typically tailored to match your symptoms and health history.
Because there can be symptom overlap between food sensitivities and food allergies, the doctor may recommend a skin prick test or blood allergy test to be sure that you don’t have a food allergy.
Unfortunately, tests cannot easily identify most food sensitivities. However, some specific intolerances can be found with testing:
- Lactose intolerance, which is the inability to properly digest a type of sugar found in milk products, can be detected with lactose tolerance tests. These include blood or breath tests that demonstrate disrupted lactose digestion.
- Celiac disease is a disorder in which a person’s immune system attacks their intestinal lining when they consume gluten, a protein found in wheat and other grains. Blood tests can help diagnose celiac disease by analyzing levels of specific antibodies, which are proteins produced by the immune system.
Some people are intolerant of gluten without having celiac disease, and this is often referred to as non-celiac gluten sensitivity (NCGS). There is no test that has been validated to accurately detect NCGS.
For most other food intolerances and sensitivities, there is no reliable test to detect them. As a result, a doctor may suggest other types of tests:
- Oral food challenge: This involves eating increasing quantities of a food over a period of hours while being closely monitored for adverse reactions. Oral food challenges follow a specific protocol and should only be done in a controlled medical setting.
- Food elimination diet: This requires following a strict diet that excludes specific foods or additives for a period of weeks. Over time, the dietary restrictions may be modified to try to identify specific intolerances or sensitivities.
People with symptoms of food reactions may have testing for other conditions such as inflammatory bowel disease, irritable bowel syndrome, or malabsorption of nutrients. Examples of tests related to these conditions are listed in the table below:
|Test Name||Test Sample||What It Measures|
|Xylose Absorption||Blood and urine||How well the body absorbs a simple sugar|
|Fecal fat||Stool||Amount of fat in a stool sample|
|Erythrocyte Sedimentation Rate (ESR)||Blood||Rate at which certain red blood cells fall when blood is placed in a test tube|
Many tests that are marketed for detecting food sensitivities and intolerances have not been proven to be accurate or effective, and experts recommend against using them. Examples of unvalidated tests include:
- Immunoglobulin-G (IgG and IgG4) antibody tests
- Hair tests
- Blood cell analysis, including flow cytometry and mediator release tests
- Provocation or neutralization testing
- Electrodermal testing
- Muscle reaction or strength tests
Getting Tested for Food Sensitivities
Food sensitivity testing is normally conducted in a doctor’s office, clinic, or medical laboratory. The procedure depends on the specific test being used. Tests are prescribed by a doctor after reviewing your symptoms to determine the most probable sensitivity or intolerance.
At-home testing is available for certain types of food sensitivities. Some tests for lactose intolerance and celiac disease can be done with at-home kits to obtain a blood sample that is then sent by mail to a laboratory. A positive result on at-home testing usually requires follow-up tests prescribed by a doctor.
Some tests are available that look for dozens of types of antibodies called immunoglobulin-G (IgG) in the blood. However, experts advise against this type of screening because it has not been shown to be accurate in identifying true food intolerance and sensitivities.
If you are concerned about a possible food sensitivity, it’s important to discuss your symptoms with your doctor to determine the most appropriate tests in your case.
Sources and Resources
These resources offer background information about food allergies and their symptoms, causes, and treatment.
- National Library of Medicine: Lactose Intolerance
- National Library of Medicine: Celiac Disease
- Merck Manual: Food Allergy
A.D.A.M. Medical Encyclopedia. Allergies. Updated February 2, 2020. Accessed March 21, 2021. https://medlineplus.gov/ency/article/000812.htm
A.D.A.M. Medical Encyclopedia. Food additives. Updated February 10, 2020. Accessed March 29, 2021. https://medlineplus.gov/ency/article/002435.htm
A.D.A.M. Medical Encyclopedia. Irritable bowel syndrome. Updated March 25, 2019. Accessed March 29, 2021. https://medlineplus.gov/ency/article/000246.htm
A.D.A.M. Medical Encyclopedia. Lactose tolerance tests. Updated June 21, 2018. Accessed March 22, 2021. https://medlineplus.gov/ency/article/003500.htm
Burks W. Diagnostic evaluation of food allergy. In: Sicherer SH, ed. UpToDate. Updated April 23, 2019. Accessed March 21, 2021. https://www.uptodate.com/contents/diagnostic-evaluation-of-food-allergy
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Cappelletti M, Tognon E, Vona L, et al. Food-specific serum IgG and symptom reduction with a personalized, unrestricted-calorie diet of six weeks in Irritable Bowel Syndrome (IBS). Nutr Metab (Lond). 2020;17(1):101. doi:10.1186/s12986-020-00528-x
Carr S, Chan E, Lavine E, Moote W. CSACI Position statement on the testing of food-specific IgG. Allergy Asthma Clin Immunol. 2012;8(1):12. Published 2012 Jul 26. doi:10.1186/1710-1492-8-12
Commins SH. Food intolerance and food allergy in adults: An overview. In: Sicherer SH, ed. UpToDate. Updated May 28, 2020. Accessed March 21, 2021. https://www.uptodate.com/contents/food-intolerance-and-food-allergy-in-adults-an-overview
Consumer Reports and the American Academy of Allergy, Asthma & Immunology. Allergy Tests: When you need them and when you don’t. Published July 1, 2012. Accessed March 23, 2021. https://www.choosingwisely.org/patient-resources/allergy-tests/
Infantino M, Manfredi M, Meacci F, et al. Diagnostic accuracy of anti-gliadin antibodies in Non Celiac Gluten Sensitivity (NCGS) patients: A dual statistical approach. Clin Chim Acta. 2015;451(Pt B):135-141. doi:10.1016/j.cca.2015.09.017
Keet C, Wood RA. Food allergy in children: Prevalence, natural history, and monitoring for resolution. In: Sicherer SH, ed. UpToDate. Updated January 8, 2019. Accessed March 26, 2021. https://www.uptodate.com/contents/food-allergy-in-children-prevalence-natural-history-and-monitoring-for-resolution
Kelso JM. Unproven and disproven tests for food allergy. In: Sicherer SH, ed. UpToDate. Updated June 4, 2020. Accessed March 21, 2021. https://www.uptodate.com/contents/unproven-and-disproven-tests-for-food-allergy
Kowal K, DuBuske L. Overview of in vitro allergy tests. In: Bochner BS, ed. UpToDate. Updated February 5, 2021. https://www.uptodate.com/contents/overview-of-in-vitro-allergy-tests
Kowal K, DuBuske L. Overview of skin testing for allergic disease. In: Bochner BS, Wood RA, eds. UpToDate. Updated April 3, 2020. Accessed March 21, 2021. https://www.uptodate.com/contents/overview-of-skin-testing-for-allergic-disease
Kvehaugen AS, Tveiten D, Farup PG. Is perceived intolerance to milk and wheat associated with the corresponding IgG and IgA food antibodies? A cross sectional study in subjects with morbid obesity and gastrointestinal symptoms. BMC Gastroenterol. 2018;18(1):22. doi:10.1186/s12876-018-0750-x
Lavine E. Blood testing for sensitivity, allergy or intolerance to food. CMAJ. 2012;184(6):666-668. doi:10.1503/cmaj.110026
MedlinePlus: National Library of Medicine. Allergy. Updated May 16, 2018. Accessed March 21, 2021. https://medlineplus.gov/allergy.html
MedlinePlus: National Library of Medicine. Food allergy testing. Updated July 31, 2020. Accessed March 22, 2021. https://medlineplus.gov/lab-tests/food-allergy-testing/
National Academies of Sciences, Engineering, and Medicine. Finding a Path to Safety in Food Allergy: Assessment of the Global Burden, Causes, Prevention, Management, and Public Policy. The National Academies Press; 2017. Accessed March 22, 2021. https://www.nap.edu/catalog/23658/finding-a-path-to-safety-in-food-allergy-assessment-of
Pawankar R, Holgate ST, Canonica W, Lockey RF, Blaiss MS, eds. White Book on Allergy 2013 Update. World Allergy Organization; 2013. Accessed March 21, 2021. https://www.worldallergy.org/UserFiles/file/WhiteBook2-2013-v8.pdf
Piuri G, Ferrazzi E, Speciani AF. Blind Analysis of Food-Related IgG Identifies Five Possible Nutritional Clusters for the Italian Population: Future Implications for Pregnancy and Lactation. Nutrients. 2019;11(5). doi:10.3390/nu11051096
Shakoor Z, AlFaifi A, AlAmro B, AlTawil LN, AlOhaly RY. Prevalence of IgG-mediated food intolerance among patients with allergic symptoms. Ann Saudi Med. 2016;36(6):386-390. doi:10.5144/0256-4947.2016.386
Sicherer SH. Oral food challenges for diagnosis and management of food allergies. In: Wood RA, ed. UpToDate. Updated June 17, 2019. Accessed March 22, 2021. https://www.uptodate.com/contents/oral-food-challenges-for-diagnosis-and-management-of-food-allergies
Sicherer SH, Allen K, Lack G, Taylor SL, Donovan SM, Oria M. Critical Issues in Food Allergy: A National Academies Consensus Report. Pediatrics. 2017;140(2). doi:10.1542/peds.2017-0194
Simon RA. Allergic and asthmatic reactions to food additives. In: Sicherer SH, ed. UpToDate. Updated July 21, 2019. Accessed March 29, 2021. https://www.uptodate.com/contents/allergic-and-asthmatic-reactions-to-food-additives
Tuck CJ, Biesiekierski JR, Schmid-Grendelmeier P, Pohl D. Food intolerances. Nutrients. 2019;11(7):1684. Published 2019 Jul 22. doi:10.3390/nu11071684
Turnbull JL, Adams HN, Gorard DA. Review article: the diagnosis and management of food allergy and food intolerances. Aliment Pharmacol Ther. 2015;41(1):3-25. doi:10.1111/apt.12984
Zeng Q, Dong S-Y, Wu L-X, et al. Variable food-specific IgG antibody levels in healthy and symptomatic Chinese adults. PLoS One. 2013;8(1):e53612. doi:10.1371/journal.pone.0053612
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