An iron disorder and form of anemia resulting from the inability to incorporate iron into hemoglobin in red blood cells (RBCs); it is characterized by the buildup of iron within developing RBCs resulting in abnormal RBCs called sideroblasts. Since the RBCs cannot develop normally, this condition causes anemia.
General term for a protein without its characteristic prosthetic group, which may be a metal or a small organic compound; for example, the protein apotransferrin combines with iron to form transferrin, and protein apoceruloplasmin combines with copper to form the enzyme ceruloplasmin.
Binding of a metal ion by a large molecule to form a soluble complex; chelation therapy uses large molecules such as EDTA (ethylene diamine tetraacetic acid) to remove excess metals (like lead or iron) from tissues and enable their excretion.