This article was last reviewed on
This article waslast modified on
April 25, 2018.

Aldolase is an enzyme that helps convert glucose into energy. It is found throughout the body but is primarily found in high levels in muscle tissue.

Because aldolase levels are elevated in the bloodstream when a person has muscle damage, the aldolase blood test may be ordered to diagnose and monitor certain conditions related to skeletal muscle. It largely has been replaced by other muscle enzyme tests, especially CK (creatine kinase). However, a minority of people with muscle pain may have an elevated aldolase level even though their CK is normal. Therefore, the test may sometimes be requested by rheumatologists in addition to CK.

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NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used.

Sources Used in Current Review

Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. Burtis CA, Ashwood AR and Bruns DE, ed. 5th ed. St. Louis, Missouri: Elsevier Saunders; 2012, Pp. 572-573.

Nozaki K, Pestronk A. High aldolase with normal creatine kinase in serum predicts a myopathy with perimysial pathology. J. Neurol Neurosurg Psychiattry 2009; 80:904-909.

Sources Used in Previous Reviews

Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. Burtis CA, Ashwood ER and Bruns DE, eds. 4th ed. St. Louis, Missouri: Elsevier Saunders; 2006, Pg 603.

(October 15, 2007) MedlinePlus Medical Encyclopedia: Aldolase test. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003566.htm. Accessed April 2009.

(July 12, 2007) Mayo Clinic. Dermatomyositis, Tests and Diagnosis. Available online at http://www.mayoclinic.com/health/dermatomyositis/DS00335/DSECTION=tests-and-diagnosis through http://www.mayoclinic.com. Accessed April 2009.

(July 13, 2007) Mayo Clinic. Polymyositis, Tests and Diagnosis. Available online at http://www.mayoclinic.com/health/polymyositis/DS00334/DSECTION=tests-and-diagnosis through http://www.mayoclinic.com. Accessed April 2009.

ARUP Consult. Physician's Guide: Inflammatory Myopathies. Available online at http://www.arupconsult.com/Topics/AutoimmuneDz/ConnectiveTissueDz/InflammatoryMyopathies.html# through http://www.arupconsult.com. Accessed April 2009.

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