Also Known As
DHEA-SO4
DHEA Sulfate
Formal Name
Dehydroepiandrosterone Sulfate
This article was last reviewed on
This article waslast modified on November 9, 2017.
At a Glance
Why Get Tested?

To help evaluate adrenal gland function; to detect adrenal tumors or cancers; to help determine the cause of masculine physical characteristics (virilization) in girls and women or early puberty in boys

When To Get Tested?

When a girl or woman has excess facial and body hair (hirsutism), acne, absence of menstrual periods (amenorrhea), or a woman has infertility; when a boy shows signs of very early (precocious) puberty such as deeper voice, pubic hair, or muscle development

Sample Required?

A blood sample drawn from a vein in your arm

Test Preparation Needed?

None, although women should talk to their health practitioner about the timing of the test; your healthcare provider may want to have the sample collected a week before or after your menstrual period.

You may be able to find your test results on your laboratory's website or patient portal. However, you are currently at Lab Tests Online. You may have been directed here by your lab's website in order to provide you with background information about the test(s) you had performed. You will need to return to your lab's website or portal, or contact your healthcare practitioner in order to obtain your test results.

Lab Tests Online is an award-winning patient education website offering information on laboratory tests. The content on the site, which has been reviewed by laboratory scientists and other medical professionals, provides general explanations of what results might mean for each test listed on the site, such as what a high or low value might suggest to your healthcare practitioner about your health or medical condition.

The reference ranges for your tests can be found on your laboratory report. They are typically found to the right of your results.

If you do not have your lab report, consult your healthcare provider or the laboratory that performed the test(s) to obtain the reference range.

Laboratory test results are not meaningful by themselves. Their meaning comes from comparison to reference ranges. Reference ranges are the values expected for a healthy person. They are sometimes called "normal" values. By comparing your test results with reference values, you and your healthcare provider can see if any of your test results fall outside the range of expected values. Values that are outside expected ranges can provide clues to help identify possible conditions or diseases.

While accuracy of laboratory testing has significantly evolved over the past few decades, some lab-to-lab variability can occur due to differences in testing equipment, chemical reagents, and techniques. This is a reason why so few reference ranges are provided on this site. It is important to know that you must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."

For more information, please read the article Reference Ranges and What They Mean.

What is being tested?

Dehydroepiandrosterone sulfate (DHEAS) is a male sex hormone (androgen) that is present in both men and women. This test measures the level of DHEAS in the blood.

DHEAS:

  • Plays a role in developing male secondary sexual characteristics at puberty
  • Can be converted by the body into more potent androgens, such as testosterone and androstenedione
  • Can be converted into the female hormone estrogen
     

DHEAS is produced almost exclusively by the adrenal glands, with smaller amounts being produced by a woman's ovaries and a man's testicles.

It is useful as a marker for adrenal gland function. Adrenal tumors (cancerous and non-cancerous) and adrenal hyperplasia can lead to the overproduction of DHEAS. Rarely, an ovarian tumor may produce DHEAS.

Excess DHEAS:

  • May not be noticed in adult men
  • Can cause early (precocious) puberty in young boys
  • Can lead to absence of menstrual periods (amenorrhea) and the development of masculine physical characteristics (virilization) in girls and women, such as excess body and facial hair (hirsutism)
  • Can cause a female baby to be born with genitals that are not distinctly male or female in appearance (ambiguous external genitalia)
     

How is the sample collected for testing?

A blood sample is obtained by inserting a needle into a vein in the arm.

Is any test preparation needed to ensure the quality of the sample?

No test preparation is needed. Women should talk to their health practitioner about the timing of the test. The healthcare provider may want to have the sample collected a week before or after a woman's menstrual period.

Accordion Title
Common Questions
  • How is it used?

    The test for dehydroepiandrosterone sulfate (DHEAS) is ordered along with tests for testosterone and several other male hormones (androgens) to:

    • Evaluate adrenal gland function
    • Distinguish DHEAS-secreting conditions that are caused by the adrenal glands from those that originate in the testicles or rarely in the ovaries (ovarian tumors)
    • Help diagnose tumors in the outer layer (cortex) of the adrenal gland (adrenocortical tumors) and adrenal cancers
    • Help diagnose congenital adrenal hyperplasia and adult-onset adrenal hyperplasia
       

    In women, concentrations of DHEAS are often measured, along with other hormones such as FSH, LHprolactin, estrogen, and testosterone, to help diagnose polycystic ovary syndrome (PCOS) and to help rule out other causes of infertility, lack of menstrual period (amenorrhea), and presence of excess facial and body hair (hirsutism).

    DHEAS levels may be ordered with other hormones to investigate and diagnose the cause of the development of masculine physical characteristics (virilization) in young girls and early (precocious) puberty in young boys.

  • When is it ordered?

    DHEAS levels are not routinely measured. A DHEAS test may be ordered, along with other hormone tests, whenever excess (or, more rarely, deficient) androgen production is suspected and/or when a health practitioner wants to evaluate a person's adrenal gland function.

    It may be measured when a woman presents with signs and symptoms such as amenorrhea, infertility, and/or those related to virilization. These changes vary in severity and may include:

    • A deeper voice
    • Excess facial or body hair (hirsutism)
    • Male pattern baldness
    • Muscularity
    • Acne
    • Enlargement of the Adam's apple
    • Decreased breast size
       

    It may also be ordered when a young girl shows signs of virilization or when a female infant has external genitalia that are not distinctly male or female in appearance (ambiguous genitalia).

    DHEAS may also be measured when young boys show signs of precocious puberty, the development of a deeper voice, pubic hair, muscularity, and an enlarged penis well before the age of normal puberty.

  • What does the test result mean?

    A normal DHEAS level, in addition to other normal male hormone (androgen) levels, likely indicates that the adrenal gland is functioning normally. Rarely, DHEAS may be normal when an adrenal tumor or cancer is present but is not secreting hormones.

    A high DHEAS blood level may indicate that excess DHEAS production is causing or contributing to the person's symptoms. However, an increased level of DHEAS is not diagnostic of a specific condition; it usually indicates the need for further testing to pinpoint the cause of the hormone imbalance. An elevated DHEAS may indicate an adrenocortical tumor, Cushing disease, adrenal cancer, or adrenal hyperplasia, or rarely a DHEAS-producing ovarian tumor.

    DHEAS may be elevated with polycystic ovary syndrome (PCOS) but may also be normal as this disorder is usually related to ovarian androgen production (primarily testosterone).

    A low level of DHEAS may be due to adrenal insufficiency, adrenal dysfunction, Addison disease, or hypopituitarism, a condition that causes low levels of the pituitary hormones that regulate the production and secretion of adrenal hormones.

  • Is there anything else I should know?

    DHEAS levels are normally high in both male and female newborns. They drop sharply shortly after birth, then rise again during puberty. DHEAS concentrations peak after puberty, and then, like other male and female hormones, the levels tend to decline with age.

    People taking DHEA supplements will have elevated blood levels of DHEAS. Certain antidiabetic drugs (such as metformin and troglitazone), prolactin, danazol, calcium channel blockers, and nicotine may also increase DHEAS levels. Drugs/hormones that may show decreased levels include insulin, oral contraceptives, corticosteroids, dopamine, hepatic enzyme inducers (carbamazepine, imipramine, phenytoin), fish oil, and vitamin E. It is important to inform your healthcare provider when taking any of these products.

  • Does my sample for a DHEAS level have to be drawn at a certain time of day like other hormone tests?

    Some hormones are increased in the morning while others rise and fall throughout the day. Some are released intermittently or with increased activity or in response to stress. Some hormones are higher at particular times of the month, and others are relatively stable. Blood sample collection for some hormone tests are timed so that the hormones can be evaluated at their highest or lowest levels. The DHEAS concentration, however, is stable, so your sample may be collected any time of day and it will not affect the result of the test.

  • Does everyone with elevated DHEAS have symptoms?

    Not necessarily.  It may be difficult to determine when adult men have an elevated level of DHEAS (since they already have masculine secondary sexual characteristics) and women of some ethnic groups (for example, Asian women) may have elevated levels of testosterone and DHEAS without exhibiting symptoms such as excess hair growth or acne.  Also, it should be noted that the symptoms present and their severity will vary from person to person.

  • Can the DHEAS test be performed in my doctor's office?

    No, the testing requires specialized equipment and is not performed in every laboratory. Your blood may need to be sent to a reference laboratory for testing.

  • Should everyone have a DHEAS test?

    Testing is typically only performed when a person has symptoms that suggest excess or inadequate production of DHEAS. Most people will not need to have this test performed.

View Sources

Sources Used in Current Review

Topiwala, S. (Updated 2014 April 28). DHEA-sulfate test. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003717.htm through http://www.nlm.nih.gov. Accessed September 2014.

(© 1995–2014). Dehydroepiandrosterone Sulfate (DHEA-S), Serum. Mayo Clinic Mayo Medical Laboratories [On-line information]. Available online at http://www.mayomedicallaboratories.com/test-catalog/Overview/8493 through http://www.mayomedicallaboratories.com. Accessed September 2014.

Elhomsy, G. and Griffing, G. (Updated 2012 September 10). Dehydroepiandrosterone (DHEA) Sulfate. Medscape Reference [On-line information]. Available online at http://emedicine.medscape.com/article/2088893-overview#showall through http://emedicine.medscape.com. Accessed September 2014.

Wayne, M. and Miller, C. (Updated 2014 February). Amenorrhea. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/Amenorrhea.html?client_ID=LTD#tabs=0 through http://www.arupconsult.com. Accessed September 2014.

Lucidi, R. (Updated 2013 November 11). Polycystic Ovarian Syndrome. Medscape Reference [On-line information]. Available online at http://emedicine.medscape.com/article/256806-overview through http://emedicine.medscape.com. Accessed September 2014.

Kaplowitz, P. (Updated 2013 February 11). Precocious Puberty. Medscape Reference [On-line information]. Available online at http://emedicine.medscape.com/article/924002-overview through http://emedicine.medscape.com. Accessed September 2014.

Pagana, K. D. & Pagana, T. J. (© 2011). Mosby's Diagnostic and Laboratory Test Reference 10th Edition: Mosby, Inc., Saint Louis, MO. Pp 63-64.

Clarke, W., Editor (© 2011). Contemporary Practice in Clinical Chemistry 2nd Edition: AACC Press, Washington, DC. Pg 474.

Rao LV, Pechet L, Jenkins A, et al. (2011). in Wallach's Interpretation of Diagnostic Tests. Williamson MA, Snyder LM, eds. Chapter 2 - Laboratory Tests: DEHYDROEPIANDROSTERONE SULFATE, SERUM (DHEA-SULFATE).  Lippincott Williams & Wilkins: Philadelphia.

Sources Used in Previous Reviews

Thomas, Clayton L., Editor (1997). Taber's Cyclopedic Medical Dictionary. F.A. Davis Company, Philadelphia, PA [18th Edition].

Pagana, Kathleen D. & Pagana, Timothy J. (2001). Mosby's Diagnostic and Laboratory Test Reference 5th Edition: Mosby, Inc., Saint Louis, MO.

Ribeiro, R.C., et.al. (2000 October). Adrenocortical tumors in children. St. Jude Children's Research Hospital, International Adrenocortical Tumor Registry [On-line information]. Available online at http://www.stjude.org/ipactr/reference_treatment_16.htm through http://www.stjude.org.

Dehydroepiandrosterone Sulfate, Serum. RUP's Guide to Clinical Laboratory Testing (CLT) [On-line information]. Available online at http://www.aruplab.com/guides/clt/tests/clt_a178.htm through http://www.aruplab.com.

A.D.A.M., Inc. Updated (2002 May 17, Updated). Congenital adrenal hyperplasia. MEDLINEplus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/000411.htm.

Ruppe, M. Updated (2003 January 10). DHEA-sulfate. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003717.htm.

Bradley, C. (2002 February 4). Ovarian overproduction of androgens. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/001165.htm.

Sadovsky, R. (2001 December 15). Androgen Deficiency in Women: Review of the Subject. American Family Physician, Tips from Other Journals [On-line Journal, Information from Miller, KA. Androgen deficiency in women. J. Clin Endrocrinol Metab 2001;86:2395-401]. Available online at http://www.aafp.org/afp/20011215/tips/6.html through http://www.aafp.org.

Alberta Clinical Practice Guidelines Steering Committee (2001 June, Revised). Laboratory Endocrine Testing Guidelines. Alberta Medical Association [On-line guidelines]. Available online at http://www.albertadoctors.org/resources/endocrinology.html through http://www.albertadoctors.org.

Lobo, R. and Carmina, E. (2000 June 20). The Importance of Diagnosing the Polycystic Ovary Syndrome. Annals of Internal Medicine 2000;132:989-993 [On-line Journal]. Available online at http://www.annals.org/issues/v132n12/full/200006200-00010.html through http://www.annals.org.

Adrenal Gland Disorders. The Merck Manual of Medical Information--Home Edition, Section 13. Hormonal Disorders, Chapter 146 [On-line information]. Available online at http://www.merck.com/mrkshared/mmanual_home/sec13/146.jsp through http://www.merck.com.

Pagana, Kathleen D. & Pagana, Timothy J. (© 2007). Mosby's Diagnostic and Laboratory Test Reference 8th Edition: Mosby, Inc., Saint Louis, MO. Pp 64-65.

Clarke, W. and Dufour, D. R., Editors (2006). Contemporary Practice in Clinical Chemistry, AACC Press, Washington, DC. Cook, J. Chapter 33 Adrenal Disorders, Pp 375-385.

Wu, A. (2006). Tietz Clinical Guide to Laboratory Tests, Fourth Edition. Saunders Elsevier, St. Louis, Missouri. Pp 334-339.

Hurd, R. (2006 October 25). DHEA-sulfate - serum. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003717.htm. Accessed on 7/21/07.

(© 1995-2010). Unit Code 8493: Dehydroepiandrosterone Sulfate (DHEA-S), Serum. Mayo Clinic, Mayo Medical Laboratories [On-line information]. Available online at http://www.mayomedicallaboratories.com/test-catalog/Overview/8493 through http://www.mayomedicallaboratories.com. Accessed December 2010.

Yahya Abdel-Rahman, M. et. al. (2010 August 5). Androgen Excess. eMedicine Laboratories [On-line information]. Available online at http://emedicine.medscape.com/article/273153-overview through http://emedicine.medscape.com. Accessed December 2010.

Meikle, W. and Roberts, W. (Updated 2010 June). Polycystic Ovarian Syndrome. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/PCOS.html?client_ID=LTD#tabs=0 through http://www.arupconsult.com. Accessed December 2010.

Meikle, W. et. al. (Updated 2010 April). Amenorrhea. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/Amenorrhea.html#tabs=0 through http://www.arupconsult.com. Accessed December 2010.

Eckman,A. (Updated 2010 April 20). DHEA-sulfate test. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003717.htm. Accessed December 2010.

Pagana, K. D. & Pagana, T. J. (© 2011). Mosby's Diagnostic and Laboratory Test Reference 10th Edition: Mosby, Inc., Saint Louis, MO. Pp 63-64.

Clarke, W. and Dufour, D. R., Editors (2006). Contemporary Practice in Clinical Chemistry, AACC Press, Washington, DC, Pp 381-382.

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