Also Known As
IL-6
Formal Name
Interleukin-6
This article was last reviewed on
This article waslast modified on November 5, 2017.
At a Glance
Why Get Tested?

To help evaluate conditions such as diabetes and cardiovascular disease or conditions associated with inflammation such as lupus and rheumatoid arthritis or with infection, such as sepsis

When To Get Tested?

Not commonly ordered, but may be used when an individual has been diagnosed with or has signs and symptoms associated with one of the conditions listed above

Sample Required?

A blood sample drawn from a vein in your arm

Test Preparation Needed?

None

You may be able to find your test results on your laboratory's website or patient portal. However, you are currently at Lab Tests Online. You may have been directed here by your lab's website in order to provide you with background information about the test(s) you had performed. You will need to return to your lab's website or portal, or contact your healthcare practitioner in order to obtain your test results.

Lab Tests Online is an award-winning patient education website offering information on laboratory tests. The content on the site, which has been reviewed by laboratory scientists and other medical professionals, provides general explanations of what results might mean for each test listed on the site, such as what a high or low value might suggest to your healthcare practitioner about your health or medical condition.

The reference ranges for your tests can be found on your laboratory report. They are typically found to the right of your results.

If you do not have your lab report, consult your healthcare provider or the laboratory that performed the test(s) to obtain the reference range.

Laboratory test results are not meaningful by themselves. Their meaning comes from comparison to reference ranges. Reference ranges are the values expected for a healthy person. They are sometimes called "normal" values. By comparing your test results with reference values, you and your healthcare provider can see if any of your test results fall outside the range of expected values. Values that are outside expected ranges can provide clues to help identify possible conditions or diseases.

While accuracy of laboratory testing has significantly evolved over the past few decades, some lab-to-lab variability can occur due to differences in testing equipment, chemical reagents, and techniques. This is a reason why so few reference ranges are provided on this site. It is important to know that you must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."

For more information, please read the article Reference Ranges and What They Mean.

What is being tested?

Interleukin-6 (IL-6) is a protein produced by immune cells. It helps regulate immune responses, which makes the IL-6 test potentially useful as a marker of immune system activation. IL-6 can be elevated with inflammation, infection, autoimmune disorders, cardiovascular diseases, and some leukemias. The test measures the amount of IL-6 in the blood.

Interleukin-6 is a one of a large group of molecules called cytokines. Cytokines have multiple roles to play within the body and act especially within the immune system to help direct the body's immune response. They are a part of the "inflammatory cascade" that involves the coordinated, sequential activation of immune response pathways.

IL-6 is produced by white blood cells (leukocytes) and acts on a variety of cells and tissues. It promotes differentiation of B-cells (white blood cells that produce antibodies), promotes cell growth in some cells, and inhibits growth in others. It stimulates the production of acute phase proteins. IL-6 also plays a role in body temperature regulation, bone maintenance, and brain function. It is primarily pro-inflammatory but can also have anti-inflammatory effects.

How is the sample collected for testing?

A blood sample is obtained by inserting a needle into a vein in the arm.

Is any test preparation needed to ensure the quality of the sample?

No test preparation is needed.

Accordion Title
Common Questions
View Sources

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