Lp-PLA2

At a Glance

Why Get Tested?

To help determine your risk of developing cardiovascular disease (CVD), including your risk of coronary heart disease (CHD), and ischemic stroke

When To Get Tested?

When your healthcare provider determines that you are at a moderate to high risk of developing CVD or of having an ischemic stroke; when you have a family history of CVD or CHD

Sample Required?

A blood sample drawn from a vein in your arm

Test Preparation Needed?

None

You may be able to find your test results on your laboratory's website or patient portal. However, you are currently at Lab Tests Online. You may have been directed here by your lab's website in order to provide you with background information about the test(s) you had performed. You will need to return to your lab's website or portal, or contact your healthcare practitioner in order to obtain your test results.

Lab Tests Online is an award-winning patient education website offering information on laboratory tests. The content on the site, which has been reviewed by laboratory scientists and other medical professionals, provides general explanations of what results might mean for each test listed on the site, such as what a high or low value might suggest to your healthcare practitioner about your health or medical condition.

The reference ranges for your tests can be found on your laboratory report. They are typically found to the right of your results.

If you do not have your lab report, consult your healthcare provider or the laboratory that performed the test(s) to obtain the reference range.

Laboratory test results are not meaningful by themselves. Their meaning comes from comparison to reference ranges. Reference ranges are the values expected for a healthy person. They are sometimes called "normal" values. By comparing your test results with reference values, you and your healthcare provider can see if any of your test results fall outside the range of expected values. Values that are outside expected ranges can provide clues to help identify possible conditions or diseases.

While accuracy of laboratory testing has significantly evolved over the past few decades, some lab-to-lab variability can occur due to differences in testing equipment, chemical reagents, and techniques. This is a reason why so few reference ranges are provided on this site. It is important to know that you must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."

For more information, please read the article Reference Ranges and What They Mean.

What is being tested?

Lipoprotein-associated phospholipase A₂ (Lp-PLA₂) is an enzyme that appears to play a role in the inflammation of blood vessels and is thought to help promote atherosclerosis. This test measures the amount and activity of Lp-PLA₂ in the blood.

Some recent studies have shown that Lp-PLA₂ is an independent risk marker for cardiovascular disease (CVD), including coronary heart disease (CHD), and ischemic stroke. In these studies, increased concentrations of Lp-PLA₂ were seen in many people who were diagnosed with CHD and ischemic stroke, regardless of other risk factors. These findings make this relatively new test potentially useful as one of a growing number of cardiac risk markers that are used to help determine a person's risk of developing CVD.

CVD causes more deaths in the U.S. each year than any other cause, according to the Centers for Disease Control and Prevention. CHD and ischemic stroke are both associated with the buildup of unstable fatty plaque deposits in the arteries that can lead to blockages in blood vessels and to heart attacks or brain damage. There are a variety of risk factors that have been identified as being associated with both conditions, including high blood pressure, diabetes, metabolic syndrome, smoking, obesity, high cholesterol levels, increased LDL (low-density lipoprotein, the "bad cholesterol"), and decreased HDL (high-density lipoprotein, the "good cholesterol").

Many people who have one or more of the commonly recognized risk factors will eventually develop CVD, but a significant number of people who have few or none of these risk factors will also develop CVD. This has lead researchers to look for additional markers that might identify those at increased risk of CVD.

In addition to the traditional risk factors listed above, a low level of chronic, systemic inflammation and blood vessel (vascular) inflammation are thought to contribute to overall risk for developing CVD. The hs-CRP test is associated with systemic inflammation; high levels are associated with increased CVD risk. The Lp-PLA₂ test is associated with vascular inflammation, and high levels are thought to increase the chance of cardiovascular events, including heart attack or stroke.

How is the sample collected for testing?

A blood sample is obtained by inserting a needle into a vein in the arm.

Is any test preparation needed to ensure the quality of the sample?

No test preparation is needed.

Common Questions

How is it used?

The Lp-PLA₂ test is sometimes used to help evaluate a person's risk of developing coronary heart disease (CHD) or to help determine the risk of having an ischemic stroke.

Lp-PLA₂ is an enzyme that appears to play a role in the inflammation of blood vessels and is thought to help promote atherosclerosis. Some recent studies have shown that Lp-PLA₂ is an independent risk marker for cardiovascular disease (CVD), including coronary heart disease (CHD), and ischemic stroke.

The test would typically be used to evaluate an individual who is at a moderate to elevated risk for CHD or stroke, someone with one or more other risk factors. For instance, it may be ordered when someone has normal or minimally elevated lipid levels, borderline high blood pressure (hypertension), or metabolic syndrome.

An Lp-PLA₂ test may sometimes be used along with an hs-CRP test to evaluate a person's level of underlying inflammation associated with CVD risk. However, unlike hs-CRP, the Lp-PLA₂ test is not affected by conditions other than CVD that can cause general inflammation, so it may be used when someone has an inflammatory condition, such as arthritis.

Lp-PLA₂ is a relatively new test that is not frequently ordered and its full clinical usefulness has yet to be established. It is intended to give additional information, not to replace cholesterol and other lipid level testing.

Some researchers are exploring whether treatment to lower Lp-PLA₂ levels will lower a person's risk of CHD and ischemic stroke. If the risk of CVD and stroke is decreased when Lp-PLA₂ is lowered, then the Lp-PLA₂ test may be ordered more frequently and be used to monitor a person's response to treatment.
When is it ordered?

Lp-PLA₂ is a relatively new test that is not frequently ordered. Some health practitioners may order it along with other cardiac risk markers when someone has a family history of CHD, has metabolic syndrome, and/or is considered to be at a moderate to elevated risk for CHD or ischemic stroke.
What does the test result mean?

A significantly elevated Lp-PLA₂ level indicates an increased risk for developing CHD or of having an ischemic stroke and provide a health practitioner with additional information about the tested person's overall risk.

A low or normal Lp-PLA₂ means that this factor does not contribute to the tested person's risk of CVD.

The test is not diagnostic of CHD or ischemic stroke; it is a risk indicator. Many people with increased concentrations will not develop these conditions, and some with normal levels will.
Is there anything else I should know?

While the findings from recent studies support the potential usefulness of Lp-PLA₂ in CHD and ischemic stroke risk assessment, its ultimate clinical utility has yet to be established.

The Lp-PLA₂ test is not widely available. In most cases, the blood sample will be sent to a reference laboratory and results will be available within a few days.
How deadly are strokes?

According to the American Stroke Association, stroke is the fourth leading cause of death in the United States and a leading cause of disability. More than 80% of strokes are ischemic.
Should everyone have an Lp-PLA2 test?

It is not currently indicated or recommended by major health organizations as a screen for the general population or recommended yet as a primary cardiac risk marker. Your healthcare provider can help you determine the best tests to determine your risk of developing CVD and provide you with information about changes you can make to lower your risk.

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Lp-PLA2

How is the sample collected for testing?

Is any test preparation needed to ensure the quality of the sample?

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