Also Known As
Cobalamin
Folic Acid
RBC Folate
Formal Name
Vitamin B12; Folate
This article was last reviewed on
This article waslast modified on November 5, 2017.
At a Glance
Why Get Tested?

To help diagnose one cause of anemia or neuropathy; to evaluate nutritional status in some people; to monitor the effectiveness of treatment for vitamin B12 or folate deficiency

When To Get Tested?

When you have an abnormal complete blood count (CBC) with a blood smear showing large red blood cells (macrocytosis) or abnormal (hypersegmented) neutrophils; when you have symptoms of anemia (weakness, tiredness, pale skin) and/or of neuropathy (tingling or itching sensations, eye twitching, memory loss, altered mental status); when you are being treated for vitamin B12 or folate deficiency

Sample Required?

A blood sample drawn from a vein in your arm

Test Preparation Needed?

Fasting for 6-8 hours before sample collection may be required. Certain medicines may affect the test results; your healthcare provider will advise you on which ones to stop taking.

You may be able to find your test results on your laboratory's website or patient portal. However, you are currently at Lab Tests Online. You may have been directed here by your lab's website in order to provide you with background information about the test(s) you had performed. You will need to return to your lab's website or portal, or contact your healthcare practitioner in order to obtain your test results.

Lab Tests Online is an award-winning patient education website offering information on laboratory tests. The content on the site, which has been reviewed by laboratory scientists and other medical professionals, provides general explanations of what results might mean for each test listed on the site, such as what a high or low value might suggest to your healthcare practitioner about your health or medical condition.

The reference ranges for your tests can be found on your laboratory report. They are typically found to the right of your results.

If you do not have your lab report, consult your healthcare provider or the laboratory that performed the test(s) to obtain the reference range.

Laboratory test results are not meaningful by themselves. Their meaning comes from comparison to reference ranges. Reference ranges are the values expected for a healthy person. They are sometimes called "normal" values. By comparing your test results with reference values, you and your healthcare provider can see if any of your test results fall outside the range of expected values. Values that are outside expected ranges can provide clues to help identify possible conditions or diseases.

While accuracy of laboratory testing has significantly evolved over the past few decades, some lab-to-lab variability can occur due to differences in testing equipment, chemical reagents, and techniques. This is a reason why so few reference ranges are provided on this site. It is important to know that you must use the range supplied by the laboratory that performed your test to evaluate whether your results are "within normal limits."

For more information, please read the article Reference Ranges and What They Mean.

What is being tested?

Vitamin B12 and folate are two vitamins that are part of the B complex of vitamins. They are necessary for normal red blood cell (RBC) formation, repair of tissues and cells, and synthesis of DNA, the genetic material in cells. Both are nutrients that cannot be produced in the body and must be supplied by the diet.

Vitamin B12 and folate tests measure vitamin levels in the liquid portion of the blood (serum or plasma) to detect deficiencies. Sometimes the amount of folate inside red blood cells may also be measured.

Folate refers to a natural occurring form of the vitamin, whereas folic acid refers to the supplement added to foods and drinks. It is found in leafy green vegetables, citrus fruits, dry beans and peas, liver, and yeast. Vitamin B12, also called cobalamin, is found in foods from animals, such as red meat, fish, poultry, milk, yogurt, and eggs. In recent years, fortified cereals, breads, and other grain products have also become important dietary sources of B12 and folate (identified as "folic acid" on nutritional labels).

A deficiency in either B12 or folate can lead to macrocytic anemia, where red blood cells are larger than normal. Megaloblastic anemia, a type of macrocytic anemia, is characterized by the production of fewer but larger RBCs called macrocytes, in addition to some cellular changes in the bone marrow. Other laboratory findings associated with megaloblastic anemia include decreased white blood cell (WBC) count and platelet count.

B12 is also important for nerve health and a deficiency can lead to varying degrees of neuropathy, nerve damage that can cause tingling and numbness in the affected person's hands and feet.

Folate is necessary for cell division such as is seen in a developing fetus. Folate deficiency during early pregnancy can increase the risk of neural tube defects such as spina bifida in a growing fetus.

B12 and folate deficiencies are most often caused by not getting enough of the vitamins through the diet or supplements, inadequate absorption, or by increased need as seen in pregnancy:

  • Dietary deficiencies—these are uncommon in the United States because many foods and drinks are supplemented with these vitamins, which are stored by the body. Adults typically have several years' worth of vitamin B12 stored in the liver and about 3 months of stored folate. Dietary deficiencies do not usually cause symptoms until stores of the vitamins within the body have been depleted. B12 deficiencies are sometimes seen in vegans (those who do not consume any animal products) and in their breast-fed infants.
  • Inadequate absorption—vitamin B12 absorption occurs in a series of steps. B12 is normally released from food by stomach acid and then, in the small intestine, is bound to intrinsic factor (IF), a protein made by parietal cells in the stomach. This B12-IF complex is then absorbed by the small intestine, bound by carrier proteins (transcobalamins), and enters the circulation. If a disease or condition interferes with any of these steps, then B12 absorption is impaired.
  • Increased need—this can be seen with a variety of diseases and conditions. Increased demand for folate occurs when a woman is pregnant or nursing, in early childhood, with cancers, or with chronic hemolytic anemias.

For more, see the article on Vitamin B12 and Folate Deficiencies.

How is the sample collected for testing?

A blood sample is obtained by inserting a needle into a vein in the arm.

Is any test preparation needed to ensure the quality of the sample?

Fasting for 6-8 hours before sample collection may be required. Certain medicines may affect the test results; your healthcare provider will advise you on which ones to stop taking. Ask your health practitioner or lab for specific instructions.

Accordion Title
Common Questions
  • How is it used?

    Vitamin B12 and folate are separate tests often used in conjunction to detect deficiencies and to help diagnose the cause of certain anemias, such as pernicious anemia, an autoimmune disease that affects the absorption of B12.

    B12 and folate are two vitamins that cannot be produced in the body and must be supplied by the diet. They are required for normal red blood cell (RBC) formation, repair of tissues and cells, and synthesis of DNA, the genetic material in cells. B12 is essential for proper nerve function. (For more, see the "What is being tested?" section.)

    B12 and folate tests may also be used to help evaluate an individual with an altered mental state or other behavioral changes, especially in the elderly. A B12 test may be ordered with folate, by itself, or with other screening laboratory tests such as a complete blood count (CBC), comprehensive metabolic panel (CMP), antinuclear antibody (ANA), C-reactive protein (CRP) and rheumatoid factor (RF) to help determine why a person shows signs and symptoms of a condition affecting nerves (neuropathy).

    Additionally, B12 and folate tests may be used in conjunction with an assortment of other tests to help evaluate the general health and nutritional status of a person with signs and symptoms of significant malnutrition or dietary malabsorption. This may include people with, for example, alcoholism, liver disease, gastric cancer, or individuals with malabsorption conditions such as celiac disease, inflammatory bowel disease, or cystic fibrosis.

    In those treated for known B12 and folate deficiencies, testing may be used to monitor the effectiveness of treatment. This is especially true for those who cannot properly absorb B12 and/or folate and must have lifelong treatment.

    Folate levels in the liquid portion of blood (serum) can vary based on a person's recent diet. Because red blood cells store 95% of circulating folate, a test to measure the folate level within RBCs may be used in addition to or instead of the serum test. Some health practitioners feel that the RBC folate test is a better indicator of long-term folate status and is more clinically relevant than serum folate, but there is not widespread agreement on this.

    Other laboratory tests that may be used to help detect B12 and folate deficiencies include homocysteine and methylmelonic acid (MMA). Homocysteine and MMA are elevated in B12 deficiency while only homocysteine, and not MMA, is elevated in folate deficiency. This distinction is important because giving folate to some who is B12-deficient will treat the anemia but does not treat the neurologic damage, which may be irreversible.

  • When is it ordered?

    B12 and folate levels may be ordered when a complete blood count (CBC) and/or blood smear, done as part of a health checkup or an evaluation for anemia, indicates a low red blood cell (RBC) count with the presence of large RBCs. Specifically, a high mean corpuscular volume (MCV) indicates that the RBCs are enlarged.

    Testing for B12 and folate levels may be appropriate when a person has signs and symptoms of a deficiency, such as:

    • Diarrhea
    • Dizziness
    • Fatigue, muscle weakness
    • Loss of appetite
    • Pale skin
    • Rapid heart rate, irregular heartbeats
    • Shortness of breath
    • Sore tongue and mouth
    • Tingling, numbness, and/or burning in the feet, hands, arms, and legs (with B12 deficiency)
    • Confusion or forgetfulness
    • Paranoia

    B12 and folate testing may sometimes be ordered when a person is at risk of a deficiency, such as people with a history of malnutrition or a condition related to malabsorption.

    These tests may be ordered on a regular basis for individuals being treated for malnutrition or a B12 or folate deficiency to evaluate the effectiveness of their treatments. For individuals with a condition causing a chronic deficiency, this may be part of a long-term treatment plan.

  • What does the test result mean?

    Normal B12 and folate levels may indicate that a person does not have a deficiency and that the signs and symptoms are likely due to another cause. However, normal levels may reflect the fact that a person's stored B12 and/or folate has not yet been fully depleted.

    When a B12 level is normal but a deficiency is still suspected, a health practitioner may order a methylmalonic acid (MMA) test as an early indicator of B12 deficiency.

    A low B12 and/or folate level in a person with signs and symptoms indicates that the person has a deficiency but does not necessarily reflect the severity of the anemia or associated neuropathy. Additional tests are usually done to investigate the underlying cause of the deficiency. Some causes of low B12 or folate include:

    • Dietary deficiency of folate or B12—this is uncommon in the U.S. It may be seen with general malnutrition and in vegans who do not consume any animal products. With the introduction of fortified cereals, breads, and other grain products, folate deficiency is very rare.
    • Malabsorption—both B12 and folate deficiencies may be seen with conditions that interfere with their absorption in the small intestine. These may include:
    • Heavy drinking or chronic alcoholism
    • Use of some drugs such as metformin, omeprazole, methotrexate or anti-seizure medications such as phenytoin
    • Increased need—all pregnant women need increased amounts of folate for proper fetal development and are recommended to take 400 micrograms of folic acid per day. People with cancer that has spread (metastasized) or with chronic hemolytic anemia have increased need for folate.
    • Smoking

    (For additional information, see the article Vitamin B12 and Folate Deficiencies.)

    If a person with a B12 or folate deficiency is being treated with supplements (or with B12 injections), then normal or elevated results indicate a response to treatment.

    High levels of B12 are uncommon and not usually clinically monitored. However, if someone has a condition such as chronic myeloproliferative neoplasm, diabetes, heart failure, obesity, AIDS, or severe liver disease, then that person may have an increased vitamin B12 level. Ingesting estrogens, vitamin C or vitamin A can also cause high B12 levels.

  • Is there anything else I should know?

    If a person is deficient in both B12 and folate but only takes folic acid supplements, the B12 deficiency may be masked. The anemia associated with both may be resolved, but the underlying neuropathy will persist.

    Intrinsic factor antibodies can interfere with the vitamin B12 test, producing falsely elevated results. If a person has these antibodies in their blood, the results of their B12 test must be interpreted with caution.

    The Schilling test was once ordered fairly routinely to confirm a diagnosis of pernicious anemia as the cause of a B12 deficiency. It is rarely, if ever, ordered and has fallen from favor because it involves the administration of radioactive B12. The Schilling test has been replaced, in part, by the measurement of intrinsic factor binding antibodies and parietal cell antibodies, and gastrin.

    Since folate deficiency is rarely seen in the U.S., some laboratories no longer offer the folate test. 

  • Can taking too many vitamin B12 and folic acid supplements hurt me?

    Not usually. Since B12 and folic acid are water-soluble, the body will rid itself of any excess by excreting it in the urine. However, taking folic acid can mask low B12 levels, so it can be important to be tested for both before beginning folate supplementation. Individuals who are allergic to cobalt should not take B12, and those with the hereditary eye disease Leber's disease may experience harm to the optic nerve if they take B12

  • Should everyone have vitamin B12 and folate tests?

    These tests are usually not necessary if you do not have symptoms associated with a deficiency, you do not have large red blood cells (RBCs) as determined by a complete blood count (CBC), and you do not have a disease or condition associated with malabsorption

  • Should every pregnant woman have a folate test?

    Folate levels may be tested during prenatal checkups. Folate supplementation is generally recommended for women before and during pregnancy.

  • Can I have B12 and folate tests done in my doctor's office?
    These tests require specialized equipment and are typically performed in a laboratory. 
View Sources

Sources Used for Current Review

Parietal Cell Antibodies, IgG, Serum. Mayo Medical Laboratories. Available online at http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/83728 through http://www.mayomedicallaboratories.com. Accessed February 2014.

Horowitz, D. (Updated 2014 February 25). Intrinsic Factor. MedlinePlus Medical Encyclopedia. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/002381.htm through http://www.nlm.nih.gov. Accessed February 2014.

Chen, Y. (Updated 2014 February 24). Anemia – B12 deficiency. MedlinePlus Medical Encyclopedia. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/000574.htm through http://www.nlm.nih.gov. Accessed February 2014.

(2014 August). Vitamin B12 Deficiency Evaluation. Mayo Medical Laboratories. Available online at http://www.mayomedicallaboratories.com/it-mmfiles/Vitamin_B12_Deficiency_Evaluation.pdf through http://www.mayomedicallaboratories.com. Accessed February 2014.

Test 83632 : Pernicious Anemia Cascade. Mayo Medical Laboratories. Available online at www.mayomedicallaboratories.com/interpretive-guide/?alpha=P&unit_code=83632 through http://www.mayomedicallaboratories.com. Accessed February 2014.

Singh, N. (Updated 2014 September 23). Vitamin B-12 Associated Neurological Diseases Treatment & Management. Medscape Reference. Available online at http://emedicine.medscape.com/article/1152670-treatment through http://emedicine.medscape.com. Accessed February 2014.

Maakaron, J.E. (Updated 2014 March 20). Macrocytosis Treatment and Management. Medscape Reference. Available online at http://emedicine.medscape.com/article/203858-treatment through http://emedicine.medscape.com. Accessed February 2014.

Coffey-Vega , K. (Updated 2013 March 22). Folic Acid Deficiency. Medscape. Available online at http://emedicine.medscape.com/article/200184-overview through http://emedicine.medscape.com. Accessed February 2014.

Gersten, T. (Updated 2013 September 20). Folate Deficiency. Medline Plus Medical Encyclopedia. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/000354.htm through http://www.nlm.nih.gov. Accessed February 2014.

Johnson, L. (Updated 2014 October). Folate. Merck Manual. Available online at http://www.merckmanuals.com/professional/nutritional_disorders/vitamin_deficiency_dependency_and_toxicity/folate.html through http://www.merckmanuals.com. Accessed February 2014.

Gersten, T. (Updated 2014 February 24). Vitamin B12 Level. MedlinePlus Medical Encyclopedia. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003705.htm through http://www.nlm.nih.gov. Accessed February 2014.

Gersten, T. (Reviewed 2013 September 20). Folate Deficiency. Pubmed Health. Available online at http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001394/ through http://www.ncbi.nlm.nih.gov. Accessed February 2014.

(©2015) Linus Pauling Institute. Vitamin B12. Available online at http://lpi.oregonstate.edu/infocenter/vitamins/vitaminB12/ through http://lpi.oregonstate.edu. Accessed March 2015.

(©2015) Linus Pauling Institute. Folate. Available online at http://lpi.oregonstate.edu/infocenter/vitamins/fa/ through http://lpi.oregonstate.edu. Accessed March 2015.

Scarpa E, et.al. Undetected vitamin B12 deficiency due to false normal assay results. Blood Transfus. 2013 Oct; 11(4): 627–629. Available online at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827408/ through http://www.ncbi.nlm.nih.gov. Accessed April 2015.

Sources Used for Previous Review

Thomas, Clayton L., Editor (1997). Taber's Cyclopedic Medical Dictionary. F.A. Davis Company, Philadelphia, PA [18th Edition].

Cohen, E. (2003 April 25). Medical Encyclopedia: Folate-deficiency anemia. MedlinePlus Health Information, Medical Encyclopedia. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/000551.htm through http://www.nlm.nih.gov/medlineplus/encyclopedia.html.

Brose, M. (2003 June 1). Medical Encyclopedia: Folic acid - test. MedlinePlus Health Information, Medical Encyclopedia. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003686.htm through http://www.nlm.nih.gov/medlineplus/encyclopedia.html.

Angelo, S. (2003 January 19). Medical Encyclopedia: Folic acid (folate). MedlinePlus Health Information, Medical Encyclopedia. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/002408.htm through http://www.nlm.nih.gov/medlineplus/encyclopedia.html.

Angelo, S. (2003 January 18). Medical Encyclopedia: Vitamin B12. MedlinePlus Health Information, Medical Encyclopedia. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/002403.htm through http://www.nlm.nih.gov/medlineplus/encyclopedia.html.

Folate, RBC and Serum. ARUP's Guide to Clinical Laboratory Testing. Available online at http://www.aruplab.com/guides/clt/tests/clt_a237.jsp#1149156 through http://www.aruplab.com.

Intrinsic Factor Blocking Antibody. ARUP's Guide to Clinical Laboratory Testing. Available online at http://www.aruplab.com/guides/clt/tests/clt_a23b.jsp#1152989 through http://www.aruplab.com.

Vitamin B12. ARUP's Guide to Clinical Laboratory Testing. Available online at http://www.aruplab.com/guides/clt/tests/clt_259c.jsp#1150535 through http://www.aruplab.com.

Vitamin B12 Binding Capacity. ARUP's Guide to Clinical Laboratory Testing. Available online at http://www.aruplab.com/guides/clt/tests/clt_260c.jsp#1150556 through http://www.aruplab.com.

Stevenson, R. Spina bifida. AccessMed Health Information Library, Hendrick Health System. Available online at http://www.ehendrick.org/healthy/001280.htm through http://www.ehendrick.org.

Carson-DeWitt, R. Pernicious anemia. AccessMed Health Information Library, Hendrick Health System. Available online at http://www.ehendrick.org/healthy/001049.htm through http://www.ehendrick.org.

Haggerty, M. Folic acid deficiency anemia. AccessMed Health Information Library, Hendrick Health System. Available online at http://www.ehendrick.org/healthy/000554.htm through http://www.ehendrick.org.

Patience Paradox. Folic acid. AccessMed Health Information Library, Hendrick Health System. Available online at http://www.ehendrick.org/healthy/002072.htm through http://www.ehendrick.org.

Haggerty, M. Anemias. AccessMed Health Information Library, Hendrick Health System. Available online at http://www.ehendrick.org/healthy/ through http://www.ehendrick.org.

Vitamin B12. NIH Clinical Center, Facts About Dietary Supplements. Available online at http://www.cc.nih.gov/ccc/supplements/intro.html through http://www.cc.nih.gov.

Folate. NIH Clinical Center, Facts About Dietary Supplements. Available online at http://www.cc.nih.gov/ccc/supplements/intro.html through http://www.cc.nih.gov.

Johnson, L. Vitamin B12. Merck Manual Second Home Edition, Section 12. Disorders of Nutrition and metabolism, Chapter 154. Vitamins. Available online at http://www.merck.com/pubs/mmanual_home2/sec12/ch154/ch154j.htm through http://www.merck.com.

Johnson, L. Folic Acid. Merck Manual Second Home Edition, Section 12. Disorders of Nutrition and metabolism, Chapter 154. Vitamins. Available online at http://www.merck.com/pubs/mmanual_home2/sec12/ch154/ch154k.htm through http://www.merck.com.

(2003 October). Vitamin B-12. Familydoctor.org. Available online at http://familydoctor.org/765.xml through http://familydoctor.org/765.xml.

Pagana, Kathleen D. & Pagana, Timothy J. (© 2007). Mosby's Diagnostic and Laboratory Test Reference 8th Edition: Mosby, Inc., Saint Louis, MO. Pp 460-461, 999-1000, 834-836.

Clarke, W. and Dufour, D. R., Editors (2006). Contemporary Practice in Clinical Chemistry, AACC Press, Washington, DC. Pp 405-406.

Wu, A. (2006). Tietz Clinical Guide to Laboratory Tests, Fourth Edition. Saunders Elsevier, St. Louis, Missouri. 1124-1127, 410-413.

Levin, M. (2007 March 13, Updated). Vitamin B12 level. MedlinePlus Medical Encyclopedia. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003705.htm throughhttp://www.nlm.nih.gov/medlineplus/encyclopedia.html. Accessed on 1/30/08.

Matsui, W. (2007 February 14, Updated). Anemia B12 deficiency. MedlinePlus Medical Encyclopedia. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/000574.htm throughhttp://www.nlm.nih.gov/medlineplus/encyclopedia.html. Accessed on 1/30/08.

Grund, S. (2007 August 27, Updated). Pernicious Anemia. MedlinePlus Medical Encyclopedia. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/000569.htm throughhttp://www.nlm.nih.gov/medlineplus/encyclopedia.html. Accessed on 1/30/08.

Van Voorhees, B. (2006 October 17, Updated). Folate Deficiency. MedlinePlus Medical Encyclopedia. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/000354.htm throughhttp://www.nlm.nih.gov/medlineplus/encyclopedia.html. Accessed on 1/30/08.

(Reviewed 2011 April 4). Vitamin B12. MedlinePlus Drug Information [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/druginfo/natural/926.html through http://www.nlm.nih.gov. Accessed August 2011.

(Reviewed 2011 June 24). Dietary Supplement Fact Sheet: Vitamin B12. NIH Office of Dietary Supplements [On-line information]. Available online at http://ods.od.nih.gov/factsheets/VitaminB12-QuickFacts/ through http://ods.od.nih.gov. Accessed August 2011.

Mayo Clinic Staff (2011 March 4). Vitamin Deficiency Anemia. MayoClinic.com [On-line information]. Available online at http://www.mayoclinic.com/health/vitamin-deficiency-anemia/DS00325/METHOD=print through http://www.mayoclinic.com. Accessed July 2011.

(Revised 2011 April). Pernicious Anemia. National Heart Lung and Blood Institute [On-line information]. Available online at http://www.nhlbi.nih.gov/health/dci/Diseases/prnanmia/prnanmia_what.html through http://www.nhlbi.nih.gov. Accessed August 2011.

Chen, Y. (Updated 2010 January 31). Anemia – B12 deficiency. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/000574.htm through http://www.nlm.nih.gov. Accessed August 2011.

Schick, P. (Updated 2011 May 26). Megaloblastic Anemia. Medscape Reference [On-line information]. Available online at http://emedicine.medscape.com/article/204066-overview through http://emedicine.medscape.com. Accessed August 2011.

Frank, E. et. al. (Updated 2010 September). Megaloblastic Anemia. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/MegaloblasticAnemia.html through http://www.arupconsult.com. Accessed July 2011.

Conrad, M. (Updated 2011 May 26). Pernicious Anemia. Medscape Reference [On-line information]. Available online at http://emedicine.medscape.com/article/204930-overview through http://emedicine.medscape.com. Accessed August 2011.

Dugdale, D. (Updated 2008 November 23). Pernicious anemia. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/000569.htm through http://www.nlm.nih.gov. Accessed August 2011.

OH, R. and Brown, D. (2003 March 1). Vitamin B12 Deficiency. Am Fam Physician. 2003 Mar 1;67(5):979-986. [On-line information]. Available online at http://www.aafp.org/afp/2003/0301/p979.html through http://www.aafp.org. Accessed August 2011.

Pagana, K. D. & Pagana, T. J. (© 2011). Mosby's Diagnostic and Laboratory Test Reference 10th Edition: Mosby, Inc., Saint Louis, MO. Pp 468-470, 1038-1039.

McPheresen RA, Pincus MR. Henry's Clinical Diagnosis and Management by Laboratory Methods, 22nd ed. Elsever Saunders: Philadelphia, 2011.

Jacobs DS, DeMott WR, Oxley DK. Jacobs & DeMott Laboratory Test Handbook, 5th ed. LexiComp: Cleveland2001.

Saenger AK. Red cell folate testing: Unwarranted and overutilized in the era of folic acid supplementation. November 2010 . Mayo Medical Laboratories. Available online at http://www.mayomedicallaboratories.com/articles/hottopics/transcripts/2010/2010-11a-rbc/2010-11a-rbc.html through http://www.mayomedicallaboratories.com. Accessed August 2011.

Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. Burtis CA, Ashwood ER, Bruns DE, eds. St. Louis: Elsevier Saunders; 2006, Pp1100-1103.

Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL eds, (2005). Harrison's Principles of Internal Medicine, 16th Edition, McGraw Hill, Pp 601-604.

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