2. Should everyone with suspected tuberculosis have an ADA test performed?
The ADA test is primarily performed when tuberculosis is suspected in the pleurae, and it is not routinely available in all laboratories. It will be performed when a healthcare practitioner determines that it will be useful and timely in helping to diagnose or rule out tuberculosis.
ADA is an enzyme that converts one byproduct into another byproduct. The first substance is toxic to lymphocytes and must be inactivated by ADA. With ADA deficiency, a rare inherited condition, the body makes insufficient ADA. This leads to the buildup of the toxic byproduct and can cause severe combined immunodeficiency disease (SCID). Infants with this condition have seriously compromised immune systems and may not survive without bone marrow transplantation. For more information, visit the Genetics Home Reference webpage on ADA deficiency.
This article was last reviewed on April 8, 2016. | This article was last modified on April 8, 2016.
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